Cathelicidins modulate TLR-activation and inflammation
MR Scheenstra, RM Van Harten… - Frontiers in …, 2020 - frontiersin.org
Cathelicidins are short cationic peptides that are part of the innate immune system. At first,
these peptides were studied mostly for their direct antimicrobial killing capacity, but …
these peptides were studied mostly for their direct antimicrobial killing capacity, but …
Heterogeneity of lipopolysaccharide as source of variability in bioassays and LPS-binding proteins as remedy
AC Fux, C Casonato Melo, S Michelini… - International Journal of …, 2023 - mdpi.com
Lipopolysaccharide (LPS), also referred to as endotoxin, is the major component of Gram-
negative bacteria's outer cell wall. It is one of the main types of pathogen-associated …
negative bacteria's outer cell wall. It is one of the main types of pathogen-associated …
Machine learning prediction of antimicrobial peptides
Antibiotic resistance constitutes a global threat and could lead to a future pandemic. One
strategy is to develop a new generation of antimicrobials. Naturally occurring antimicrobial …
strategy is to develop a new generation of antimicrobials. Naturally occurring antimicrobial …
Composites based on gellan gum, alginate and nisin-enriched lipid nanoparticles for the treatment of infected wounds
K Reczyńska-Kolman, K Hartman, K Kwiecień… - International Journal of …, 2021 - mdpi.com
Due to growing antimicrobial resistance to antibiotics, novel methods of treatment of infected
wounds are being searched for. The aim of this research was to develop a composite wound …
wounds are being searched for. The aim of this research was to develop a composite wound …
Upregulating human cathelicidin antimicrobial peptide LL-37 expression may prevent severe COVID-19 inflammatory responses and reduce microthrombosis
KM Aloul, JE Nielsen, EB Defensor, JS Lin… - Frontiers in …, 2022 - frontiersin.org
COVID-19 is characterized by hyperactivation by inflammatory cytokines and recruitment of
macrophages, neutrophils, and other immune cells, all hallmarks of a strong inflammatory …
macrophages, neutrophils, and other immune cells, all hallmarks of a strong inflammatory …
Antimicrobial and amyloidogenic activity of peptides. Can antimicrobial peptides be used against SARS-CoV-2?
SR Kurpe, SY Grishin, AK Surin, AV Panfilov… - International Journal of …, 2020 - mdpi.com
At present, much attention is paid to the use of antimicrobial peptides (AMPs) of natural and
artificial origin to combat pathogens. AMPs have several points that determine their …
artificial origin to combat pathogens. AMPs have several points that determine their …
Machine learning uncovers adverse drug effects on intestinal bacteria
The human gut microbiome, composed of trillions of microorganisms, plays an essential role
in human health. Many factors shape gut microbiome composition over the life span …
in human health. Many factors shape gut microbiome composition over the life span …
Modulation of innate immunity in airway epithelium for host-directed therapy
IT Myszor, GH Gudmundsson - Frontiers in Immunology, 2023 - frontiersin.org
Innate immunity of the mucosal surfaces provides the first-line defense from invading
pathogens and pollutants conferring protection from the external environment. Innate …
pathogens and pollutants conferring protection from the external environment. Innate …
[HTML][HTML] Proteinous components of neutrophil extracellular traps are arrested by the cell wall proteins of Candida albicans during fungal infection, and can be used in …
J Karkowska-Kuleta, M Smolarz, K Seweryn-Ozog… - Cells, 2021 - mdpi.com
One of defense mechanisms of the human immune system to counteract infection by the
opportunistic fungal pathogen Candida albicans is the recruitment of neutrophils to the site …
opportunistic fungal pathogen Candida albicans is the recruitment of neutrophils to the site …
Targeting infectious agents as a therapeutic strategy in Alzheimer's disease
Alzheimer's disease (AD) is the most prevalent dementia in the world. Its cause (s) are
presently largely unknown. The most common explanation for AD, now, is the amyloid …
presently largely unknown. The most common explanation for AD, now, is the amyloid …