Cathelicidins modulate TLR-activation and inflammation

MR Scheenstra, RM Van Harten… - Frontiers in …, 2020 - frontiersin.org
Cathelicidins are short cationic peptides that are part of the innate immune system. At first,
these peptides were studied mostly for their direct antimicrobial killing capacity, but …

Heterogeneity of lipopolysaccharide as source of variability in bioassays and LPS-binding proteins as remedy

AC Fux, C Casonato Melo, S Michelini… - International Journal of …, 2023 - mdpi.com
Lipopolysaccharide (LPS), also referred to as endotoxin, is the major component of Gram-
negative bacteria's outer cell wall. It is one of the main types of pathogen-associated …

Machine learning prediction of antimicrobial peptides

G Wang, II Vaisman, ML van Hoek - Computational peptide science …, 2022 - Springer
Antibiotic resistance constitutes a global threat and could lead to a future pandemic. One
strategy is to develop a new generation of antimicrobials. Naturally occurring antimicrobial …

Composites based on gellan gum, alginate and nisin-enriched lipid nanoparticles for the treatment of infected wounds

K Reczyńska-Kolman, K Hartman, K Kwiecień… - International Journal of …, 2021 - mdpi.com
Due to growing antimicrobial resistance to antibiotics, novel methods of treatment of infected
wounds are being searched for. The aim of this research was to develop a composite wound …

Upregulating human cathelicidin antimicrobial peptide LL-37 expression may prevent severe COVID-19 inflammatory responses and reduce microthrombosis

KM Aloul, JE Nielsen, EB Defensor, JS Lin… - Frontiers in …, 2022 - frontiersin.org
COVID-19 is characterized by hyperactivation by inflammatory cytokines and recruitment of
macrophages, neutrophils, and other immune cells, all hallmarks of a strong inflammatory …

Antimicrobial and amyloidogenic activity of peptides. Can antimicrobial peptides be used against SARS-CoV-2?

SR Kurpe, SY Grishin, AK Surin, AV Panfilov… - International Journal of …, 2020 - mdpi.com
At present, much attention is paid to the use of antimicrobial peptides (AMPs) of natural and
artificial origin to combat pathogens. AMPs have several points that determine their …

Machine learning uncovers adverse drug effects on intestinal bacteria

LE McCoubrey, M Elbadawi, M Orlu, S Gaisford… - Pharmaceutics, 2021 - mdpi.com
The human gut microbiome, composed of trillions of microorganisms, plays an essential role
in human health. Many factors shape gut microbiome composition over the life span …

Modulation of innate immunity in airway epithelium for host-directed therapy

IT Myszor, GH Gudmundsson - Frontiers in Immunology, 2023 - frontiersin.org
Innate immunity of the mucosal surfaces provides the first-line defense from invading
pathogens and pollutants conferring protection from the external environment. Innate …

[HTML][HTML] Proteinous components of neutrophil extracellular traps are arrested by the cell wall proteins of Candida albicans during fungal infection, and can be used in …

J Karkowska-Kuleta, M Smolarz, K Seweryn-Ozog… - Cells, 2021 - mdpi.com
One of defense mechanisms of the human immune system to counteract infection by the
opportunistic fungal pathogen Candida albicans is the recruitment of neutrophils to the site …

Targeting infectious agents as a therapeutic strategy in Alzheimer's disease

T Fülöp, U Munawara, A Larbi, M Desroches… - CNS drugs, 2020 - Springer
Alzheimer's disease (AD) is the most prevalent dementia in the world. Its cause (s) are
presently largely unknown. The most common explanation for AD, now, is the amyloid …