We review the molecular basis of several transcription factors (Eya1, Sox2), including the
three related genes coding basic helix–loop–helix (bHLH; see abbreviations) proteins …

Age-related hearing loss (ARHL) is a common, increasing problem for older adults, affecting
about 1 billion people by 2050. We aim to correlate the different reductions of hearing from …

A cardinal feature of the auditory pathway is frequency selectivity, represented in a tonotopic
map from the cochlea to the cortex. The molecular determinants of the auditory frequency …

Auditory processing in mammals begins in the peripheral inner ear and extends to the
auditory cortex. Sound is transduced from mechanical stimuli into electrochemical signals of …

Ribbon‐class synapses in the ear achieve analog to digital transformation of a continuously
graded membrane potential to all‐or‐none spikes. In mammals, several auditory nerve …

Hearing depends on extracting frequency, intensity, and temporal properties from sound to
generate an auditory map for acoustical signal processing. How physiology intersects with …

Interaction with the world around us requires extracting meaningful signals to guide
behavior. Each of the six mammalian senses (olfaction, vision, somatosensation, hearing …

Reductions in sound-evoked activity in the auditory nerve due to hearing loss have been
shown to cause pathological changes in central auditory structures. Hearing loss due strictly …

In the mammalian organ of Corti (OC), the stereocilia on the apical surface of hair cells
(HCs) are uniformly organized in a neural to abneural axis (or medial-laterally). This …

Studies by His from 1868 to 1904 delineated the critical role of the dorsal roof plate in the
development of the hindbrain choroid plexus, and of the rhombic lips in the development of …