Inflammasomes are critical sentinels of the innate immune system that respond to threats to
the host through recognition of distinct molecules, known as pathogen-or damage …

The regulated disruption of the plasma membrane, which can promote cell death, cytokine
secretion or both is central to organismal health. The protein gasdermin D (GSDMD) is a key …

According to the endosymbiotic theory, most of the DNA of the original bacterial
endosymbiont has been lost or transferred to the nucleus, leaving a much smaller (∼ 16 kb …

Ferroptosis is a form of regulated cell death induced by iron-dependent lipid peroxidation,
and it has been studied extensively since its discovery in 2012. Induced by iron overload …

Diseases associated with chronic inflammation constitute a major health burden across the
world. As central instigators of the inflammatory response to infection and tissue damage …

Plasma membrane perforation elicited by caspase cleavage of the gasdermin D (GSDMD) N-
terminal domain (GSDMD-NT) triggers pyroptosis. The mechanisms underlying GSDMD …

Mitochondrial dysfunction and axon loss are hallmarks of neurologic diseases. Gasdermin
(GSDM) proteins are executioner pore-forming molecules that mediate cell death, yet their …

Reactive oxygen species (ROS) in biological systems are transient but essential molecules
that are generated and eliminated by a complex set of delicately balanced molecular …

Inflammasomes are macromolecular platforms formed in response to damage-associated
molecular patterns (DAMPs) and pathogen-associated molecular patterns, whose formation …

Gasdermin D (GSDMD)-mediated pyroptosis and downstream inflammation are important
self-protection mechanisms against stimuli and infections. Hosts can defend against …