Zebrafish are increasingly being utilized as a model system to investigate the function of the
growing list of risk genes associated with neurodevelopmental disorders. This is due in large …

The dosage of the serine threonine kinase DYRK1A is critical in the central nervous system
(CNS) during development and aging. This review analyzes the functions of this kinase by …

For the past few years there has been an exponential increase in the use of animal models
to confirm the pathogenicity of candidate disease-causing genetic variants found in patients …

Autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD) are two
debilitating neurodevelopmental disorders. The former is associated with social impairments …

Using a novel rat model of Down syndrome (DS), the functional role of the cystathionine-β-
synthase (CBS)/hydrogen sulfide (H 2 S) pathway was investigated on the pathogenesis of …

Autism spectrum disorder (ASD) refers to a complicated range of childhood
neurodevelopmental disorders which can occur via genetic or non-genetic factors. Clinically …

Neurodevelopmental disorders (NDDs) caused by aberrant brain growth and development
are life-long, debilitating illnesses that markedly impair the quality of life. Animal models are …

Autism spectrum disorders (ASDs) are a highly variable and complex set of neurological
disorders that alter neurodevelopment and cognitive function, which usually presents with …

As an important part in international disease, mental disorders seriously damage human
health and social stability, which show the complex pathogenesis and increasing incidence …

Social behaviors are essential for the survival and reproduction of social species. Many, if
not most, neuropsychiatric disorders in humans are either associated with underlying social …