[HTML][HTML] The multifaced role of STAT3 in cancer and its implication for anticancer therapy
M Tolomeo, A Cascio - International journal of molecular sciences, 2021 - mdpi.com
Signal transducer and activator of transcription (STAT) 3 is one of the most complex
regulators of transcription. Constitutive activation of STAT3 has been reported in many types …
regulators of transcription. Constitutive activation of STAT3 has been reported in many types …
Targeting the STAT3 signaling pathway in cancer: role of synthetic and natural inhibitors
Signal transducers and activators of transcription (STATs) comprise a family of cytoplasmic
transcription factors that mediate intracellular signaling that is usually generated at cell …
transcription factors that mediate intracellular signaling that is usually generated at cell …
[HTML][HTML] Testosterone is responsible for enhanced susceptibility of males to ischemic renal injury
KM Park, JI Kim, Y Ahn, AJ Bonventre… - Journal of Biological …, 2004 - ASBMB
Female mice are much more resistant to ischemia/reperfusion (I/R)-induced kidney injury
when compared with males. Although estrogen administration can partially reduce kidney …
when compared with males. Although estrogen administration can partially reduce kidney …
Targeting STAT3 in cancer and autoimmune diseases
T Gharibi, Z Babaloo, A Hosseini… - European journal of …, 2020 - Elsevier
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is
activated downstream of a broad range of receptors particularly interleukin-6 (IL-6) family …
activated downstream of a broad range of receptors particularly interleukin-6 (IL-6) family …
[HTML][HTML] Epstein-Barr virus latent membrane protein 1 (LMP1) activates the phosphatidylinositol 3-kinase/Akt pathway to promote cell survival and induce actin filament …
CW Dawson, G Tramountanis, AG Eliopoulos… - Journal of Biological …, 2003 - ASBMB
The Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) is an integral membrane
protein that functions as a constitutively activated member of the tumor necrosis factor …
protein that functions as a constitutively activated member of the tumor necrosis factor …
Small molecule inhibitors of signal transducer and activator of transcription 3 (Stat3) protein
Stat3 was independently discovered and studied by two research groups and described in
1994. Akira et al. purified and cloned Stat3 from mouse liver nuclear extracts, named it as …
1994. Akira et al. purified and cloned Stat3 from mouse liver nuclear extracts, named it as …
Live and let die: regulatory mechanisms in Fas-mediated apoptosis
JF Curtin, TG Cotter - Cellular signalling, 2003 - Elsevier
Activation of Fas receptor by Fas ligand causes caspase 8 activation and apoptosis in cells
and is an important mechanism by which normal tissue homeostasis and function are …
and is an important mechanism by which normal tissue homeostasis and function are …
Neuroprotection against focal ischemic brain injury by inhibition of c-Jun N-terminal kinase and attenuation of the mitochondrial apoptosis-signaling pathway
c-Jun N-terminal kinase (JNK) is an important stress-responsive kinase that is activated by
various forms of brain insults. In this study, we have examined the role of JNK activation in …
various forms of brain insults. In this study, we have examined the role of JNK activation in …
Death receptors and melanoma resistance to apoptosis
Impaired ability to undergo programmed cell death in response to a wide range of external
stimuli acquires melanomas a selective advantage for progression and metastasis as well …
stimuli acquires melanomas a selective advantage for progression and metastasis as well …