Possible side effects of polyphenols and their interactions with medicines

A Duda-Chodak, T Tarko - Molecules, 2023 - mdpi.com
Polyphenols are an important component of plant-derived food with a wide spectrum of
beneficial effects on human health. For many years, they have aroused great interest …

Polyphenols in cancer prevention: New insights

G Briguglio, C Costa, M Pollicino… - International …, 2020 - spandidos-publications.com
A huge volume of literature data suggests that a diet rich in fruits and vegetables, mostly due
to the contribution of natural polyphenols, could reduce the incidence of specific cancers …

The signaling pathways and targets of traditional Chinese medicine and natural medicine in triple-negative breast cancer

Z Yang, Q Zhang, L Yu, J Zhu, Y Cao, X Gao - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance Triple-negative breast cancer (TNBC) has a poorer
prognosis than other subtypes due to its strong invasion and higher risk of distant …

Role of STAT3 in the initiation, progression, proliferation and metastasis of breast cancer and strategies to deliver JAK and STAT3 inhibitors

YH Dinakar, H Kumar, SL Mudavath, R Jain, R Ajmeer… - Life Sciences, 2022 - Elsevier
Introduction Breast cancer (BC) accounts for the majority of cancers among the female
population. Anomalous activation of various signaling pathways has become an issue of …

Oxidative stress inducers in cancer therapy: Preclinical and clinical evidence

ZN Nizami, HE Aburawi, A Semlali, K Muhammad… - Antioxidants, 2023 - mdpi.com
Reactive oxygen species (ROS) are metabolic byproducts that regulate various cellular
processes. However, at high levels, ROS induce oxidative stress, which in turn can trigger …

Ginsenoside Rh1 prevents migration and invasion through mitochondrial ROS-mediated inhibition of STAT3/NF-κB signaling in MDA-MB-231 cells

Y Jin, DTN Huynh, CS Myung, KS Heo - International journal of molecular …, 2021 - mdpi.com
Breast cancer (BC) a very common cancer in women worldwide. Triple negative breast
cancer (TNBC) has been shown to have a poor prognosis with a high level of tumor …

Carnosol inhibits KGN cells oxidative stress and apoptosis and attenuates polycystic ovary syndrome phenotypes in mice through Keap1‐mediated Nrf2/HO‐1 …

R Ji, F Jia, X Chen, Y Gao, J Yang - Phytotherapy Research, 2023 - Wiley Online Library
Excessive oxidative stress and apoptosis of ovarian granulosa cells lead to abnormal
follicular development and ovulation disorders in polycystic ovary syndrome (PCOS) …

Proteomic profiling of serum exosomes from patients with metastatic gastric cancer

XQ Ding, ZY Wang, D Xia, RX Wang, XR Pan… - Frontiers in …, 2020 - frontiersin.org
Background: Clinical management of metastatic gastric cancer (mGC) remains a major
challenge due to a lack of specific biomarkers and effective therapeutic targets. Recently …

Targeting Triple-Negative Breast Cancer by the Phytopolyphenol Carnosol: ROS-Dependent Mechanisms

H Alsamri, Y Al Dhaheri, R Iratni - Antioxidants, 2023 - mdpi.com
Triple-negative breast cancer (TNBC), which lacks the expression of the three hormone
receptors (ie, estrogen receptor, progesterone receptor, and human epidermal growth factor …

Carnosol induces p38-mediated ER stress response and autophagy in human breast cancer cells

H Alsamri, A Alneyadi, K Muhammad, MA Ayoub… - Frontiers in …, 2022 - frontiersin.org
We recently reported that carnosol induces ROS-dependent autophagy and apoptosis in
breast cancer cells. We also reported that carnosol inhibits breast cancer cell migration …