Autoreactive lymphocytes in multiple sclerosis: Pathogenesis and treatment target

R Liu, S Du, L Zhao, S Jain, K Sahay… - Frontiers in …, 2022 - frontiersin.org
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system
(CNS) characterized by destruction of the myelin sheath structure. The loss of myelin leads …

[HTML][HTML] Role of smoking in the pathogenesis of multiple sclerosis: a review article

K Nishanth, E Tariq, FP Nzvere, M Miqdad… - Cureus, 2020 - ncbi.nlm.nih.gov
Multiple sclerosis (MS) is a complex and unpredictable neurological condition. It is the most
commonly seen autoimmune disorder. The incidence of disease and its prevalence are …

GPR15 facilitates recruitment of regulatory T cells to promote colorectal cancer

A Adamczyk, E Pastille, J Kehrmann, VP Vu, R Geffers… - Cancer research, 2021 - AACR
Colorectal cancer is one of the most frequent malignancies worldwide. Despite considerable
progress in early detection and treatment, there is still an unmet need for novel antitumor …

Increased IFN-γ-producing Th17/Th1 cells and their association with lung function and current smoking status in patients with chronic obstructive pulmonary disease

W Xu, R Li, Y Sun - BMC Pulmonary Medicine, 2019 - Springer
Background Th17 cells are believed to be important proinflammatory cells in the
pathogenesis of chronic obstructive pulmonary disease (COPD). Recent evidence …

Ellagic acid effects on disease severity, levels of cytokines and T-bet, RORγt, and GATA3 genes expression in multiple sclerosis patients: a multicentral-triple blind …

S Jafari Karegar, N Aryaeian, G Hajiluian… - Frontiers in …, 2023 - frontiersin.org
Background Multiple sclerosis (MS) is a chronic autoimmune disease. Ellagic acid is a
natural polyphenol and affects the fate of neurons through its anti-inflammatory and …

G protein-coupled receptor 15 expression is associated with myocardial infarction

T Haase, C Müller, B Stoffers, P Kirn… - International journal of …, 2022 - mdpi.com
Beyond the influence of lifestyle-related risk factors for myocardial infarction (MI), the
mechanisms of genetic predispositions for MI remain unclear. We sought to identify and …

Immune changes beyond Th2 pathways during rapid multifood immunotherapy enabled with omalizumab

M Manohar, D Dunham, S Gupta, Z Yan, W Zhang… - Allergy, 2021 - Wiley Online Library
Background Multifood oral immunotherapy (mOIT) with adjunctive anti‐IgE (omalizumab,
XOLAIR®) treatment affords safe, effective, and rapid desensitization to multiple foods …

[HTML][HTML] Smoking and osteoimmunology: Understanding the interplay between bone metabolism and immune homeostasis

G Xie, C Huang, S Jiang, H Li, Y Gao, T Zhang… - Journal of Orthopaedic …, 2024 - Elsevier
Smoking continues to pose a global threat to morbidity and mortality in populations. The
detrimental impact of smoking on health and disease includes bone destruction and immune …

GPR15 expressed in T lymphocytes from RA patients is involved in leukocyte chemotaxis to the synovium

JC Fernández-Ruiz, FL Ochoa-González… - Journal of Leukocyte …, 2022 - academic.oup.com
The rheumatoid arthritis (RA) inflammatory process occurs in the joints where immune cells
are attracted into the synovium to promote remodeling and tissue damage. GPR15 is a G …

Environmental and nutritional “stressors” and oligodendrocyte dysfunction: role of mitochondrial and endoplasmatic reticulum impairment

J Maiuolo, M Gliozzi, V Musolino, C Carresi, S Nucera… - Biomedicines, 2020 - mdpi.com
Oligodendrocytes are myelinating cells of the central nervous system which are generated
by progenitor oligodendrocytes as a result of maturation processes. The main function of …