Regulation of pancreatic beta-cell mass
L Bouwens, I Rooman - Physiological reviews, 2005 - journals.physiology.org
Beta-cell mass regulation represents a critical issue for understanding diabetes, a disease
characterized by a near-absolute (type 1) or relative (type 2) deficiency in the number of …
characterized by a near-absolute (type 1) or relative (type 2) deficiency in the number of …
An illustrated review of early pancreas development in the mouse
MC Jørgensen, J Ahnfelt-Rønne, J Hald… - Endocrine …, 2007 - academic.oup.com
Pancreas morphogenesis and cell differentiation are highly conserved among vertebrates
during fetal development. The pancreas develops through simple budlike structures on the …
during fetal development. The pancreas develops through simple budlike structures on the …
DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients
M Volkmar, S Dedeurwaerder, DA Cunha… - The EMBO …, 2012 - embopress.org
In addition to genetic predisposition, environmental and lifestyle factors contribute to the
pathogenesis of type 2 diabetes (T2D). Epigenetic changes may provide the link for …
pathogenesis of type 2 diabetes (T2D). Epigenetic changes may provide the link for …
[HTML][HTML] The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into α and subsequently β cells
P Collombat, X Xu, P Ravassard, B Sosa-Pineda… - Cell, 2009 - cell.com
We have previously reported that the loss of Arx and/or Pax4 gene activity leads to a shift in
the fate of the different endocrine cell subtypes in the mouse pancreas, without affecting the …
the fate of the different endocrine cell subtypes in the mouse pancreas, without affecting the …
Differentiated human stem cells resemble fetal, not adult, β cells
Human pluripotent stem cells (hPSCs) have the potential to generate any human cell type,
and one widely recognized goal is to make pancreatic β cells. To this end, comparisons …
and one widely recognized goal is to make pancreatic β cells. To this end, comparisons …
Monogenic diabetes: what it teaches us on the common forms of type 1 and type 2 diabetes
Y Yang, L Chan - Endocrine reviews, 2016 - academic.oup.com
To date, more than 30 genes have been linked to monogenic diabetes. Candidate gene and
genome-wide association studies have identified> 50 susceptibility loci for common type 1 …
genome-wide association studies have identified> 50 susceptibility loci for common type 1 …
[HTML][HTML] PAX4 loss of function increases diabetes risk by altering human pancreatic endocrine cell development
HH Lau, NAJ Krentz, F Abaitua… - Nature …, 2023 - nature.com
The coding variant (p. Arg192His) in the transcription factor PAX4 is associated with an
altered risk for type 2 diabetes (T2D) in East Asian populations. In mice, Pax4 is essential for …
altered risk for type 2 diabetes (T2D) in East Asian populations. In mice, Pax4 is essential for …
[HTML][HTML] PI3K/PTEN/Akt and TSC/mTOR signaling pathways, ovarian dysfunction, and infertility: an update
The α and β cells act in concert to maintain blood glucose. The α cells release glucagon in
response to low levels of glucose to stimulate glycogenolysis in the liver. In contrast, β cells …
response to low levels of glucose to stimulate glycogenolysis in the liver. In contrast, β cells …
[HTML][HTML] The biology of activin: recent advances in structure, regulation and function
Y Xia, AL Schneyer - The Journal of endocrinology, 2009 - ncbi.nlm.nih.gov
Activin was discovered in the 1980's as a gonadal protein that stimulated FSH release from
pituitary gonadotropes and was thought of as a reproductive hormone. In the ensuing …
pituitary gonadotropes and was thought of as a reproductive hormone. In the ensuing …
[HTML][HTML] The role of transcription factors in the transdifferentiation of pancreatic islet cells
T van der Meulen, MO Huising - Journal of molecular …, 2015 - ncbi.nlm.nih.gov
Alpha and beta cells act in concert to maintain blood glucose. Alpha cells release glucagon
in response to low glucose to stimulate glycogenolysis in the liver. In contrast, beta cells …
in response to low glucose to stimulate glycogenolysis in the liver. In contrast, beta cells …