Neuroinflammation is a complex biological process that plays a significant role in various
brain disorders. Microglia and astrocytes are the key cell types involved in inflammatory …

Pooled optical screens have enabled the study of cellular interactions, morphology, or
dynamics at massive scale, but have not yet leveraged the power of highly-plexed single …

Non-coding RNAs play important roles in tumor cells and macrophages and participate in
their communication as messengers. Non-coding RNAs have an impact in tumor cell …

Fever-range hyperthermia (FRH) is utilized in chronic disease treatment and serves as a
model for fever's thermal component investigation. Macrophages, highly susceptible to heat …

Macrophages (MΦ) are commonly cultured in vitro as a model of their biology and functions
in tissues. Recent evidence suggests MΦ to engage in quorum sensing, adapting their …

Despite advancements in treatment, approximately 25% of breast cancer patients
experience long-term skeletal muscle wasting (SMW), which limits mobility, reduces drug …

Abstract Erythroid differentiation regulator 1 (Erdr1) is a stress-induced, widely distributed,
extremely conserved secreted factor found in both humans and mice. Erdr1 is highly linked …

Human induced pluripotent stem cell (hiPSC)-derived macrophages provide a valuable tool
for disease modeling and drug discovery. Here, we present a protocol to generate functional …

Treatment of mutant isocitrate dehydrogenase 1 (IDH1) glioma remains challenging;
targeted allosteric inhibitors currently provide limited clinical effect. Resistance to mutIDH1 …