[HTML][HTML] Tropomyosin receptor kinase (TRK) biology and the role of NTRK gene fusions in cancer
The tropomyosin receptor kinase (TRK) family of receptor tyrosine kinases are encoded by
NTRK genes and have a role in the development and normal functioning of the nervous …
NTRK genes and have a role in the development and normal functioning of the nervous …
Molecular genetics and diagnosis of thyroid cancer
YE Nikiforov, MN Nikiforova - Nature Reviews Endocrinology, 2011 - nature.com
Thyroid cancer is a common type of endocrine malignancy, and its incidence has been
steadily increasing in many regions of the world. Initiation and progression of thyroid cancer …
steadily increasing in many regions of the world. Initiation and progression of thyroid cancer …
Targeting TRK family proteins in cancer
YB Khotskaya, VR Holla, AF Farago, KRM Shaw… - Pharmacology & …, 2017 - Elsevier
The tropomyosin receptor kinase (TRK) family includes TRKA, TRKB, and TRKC proteins,
which are encoded by NTRK1, NTRK2 and NTRK3 genes, respectively. Binding of …
which are encoded by NTRK1, NTRK2 and NTRK3 genes, respectively. Binding of …
[图书][B] Pathology and genetics of tumours of endocrine organs
RA DeLellis - 2004 - books.google.com
This volume covers tumors of the pituary, the thyroid and parathyroid, the adrenal gland, the
endocrine pancreas, and inherited tumor syndromes. Each entity is extensively discussed …
endocrine pancreas, and inherited tumor syndromes. Each entity is extensively discussed …
Tyrosine kinases as targets for cancer therapy
DS Krause, RA Van Etten - New England Journal of Medicine, 2005 - Mass Medical Soc
Tyrosine kinases, enzymes that catalyze the transfer of phosphate from ATP to tyrosine
residues in polypeptides, are ubiquitous, numerous, and of considerable clinical interest …
residues in polypeptides, are ubiquitous, numerous, and of considerable clinical interest …
Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system
T Iwahara, J Fujimoto, D Wen, R Cupples, N Bucay… - Oncogene, 1997 - nature.com
The 2; 5 chromosomal translocation is frequently associated with anaplastic large cell
lymphomas (ALCLs). The translocation creates a fusion gene consisting of the alk …
lymphomas (ALCLs). The translocation creates a fusion gene consisting of the alk …
BRAF Mutations in Thyroid Tumors Are Restricted to Papillary Carcinomas and Anaplastic or Poorly Differentiated Carcinomas Arising from Papillary Carcinomas
MN Nikiforova, ET Kimura, M Gandhi… - The Journal of …, 2003 - academic.oup.com
Activating point mutations of the BRAF gene have been recently reported in papillary thyroid
carcinomas. In this study, we analyzed 320 thyroid tumors and six anaplastic carcinoma cell …
carcinomas. In this study, we analyzed 320 thyroid tumors and six anaplastic carcinoma cell …
Dimerization of cell surface receptors in signal transduction
CH Heldin - Cell, 1995 - Elsevier
Cell growth, differentiation, migration, and apoptosis are in part regulated by polypeptide
growth factors or cytokines. As these factors are unable to pass the hydrophobic cell …
growth factors or cytokines. As these factors are unable to pass the hydrophobic cell …
Emerging Targeted Therapy for Tumors with NTRK Fusion Proteins
ES Kheder, DS Hong - Clinical Cancer Research, 2018 - AACR
The oncogenesis-promoting role of chromosomal rearrangements for several hematologic
and solid malignancies is well recognized. However, identifying targetable, actionable, and …
and solid malignancies is well recognized. However, identifying targetable, actionable, and …
Tyrosine kinase gene rearrangements in epithelial malignancies
Chromosomal rearrangements that lead to oncogenic kinase activation are observed in
many epithelial cancers. These cancers express activated fusion kinases that drive the …
many epithelial cancers. These cancers express activated fusion kinases that drive the …