Targeting tumor cell metabolism is an attractive form of therapy, as it may enhance treatment
response in therapy resistant cancers as well as mitigate treatment-related toxicities by …

Glutamine metabolism is reprogrammed during tumorigenesis and has been investigated as
a promising target for cancer therapy. However, efforts to drug this process are confounded …

Summary N 6-Methyladenosine (m 6 A) modification and its modulators play critical roles
and show promise as therapeutic targets in human cancers, including acute myeloid …

Like normal hematopoietic stem cells, leukemic stem cells depend on their bone marrow
(BM) microenvironment for survival, but the underlying mechanisms remain largely …

Metabolism rewiring is an important hallmark of cancers. Being one of the most abundant
free amino acids in the human blood, glutamine supports bioenergetics and biosynthesis …

Although transcription factor CCAAT-enhancer binding protein α (C/EBPα) is critical for
normal and leukemic differentiation, its role in cell and metabolic homeostasis is largely …

Metabolic disorders and abnormal immune function changes occur in tumor tissues and
cells to varying degrees. There is increasing evidence that reprogrammed energy …

Tumor cells rewire metabolic pathways to adapt to their increased nutritional demands for
energy, reducing equivalents, and cellular biosynthesis. Alternations in amino acid …

Acute myeloid leukemia (AML) is characterized by the presence of leukemia stem cells
(LSCs), and failure to fully eradicate this population contributes to disease …

Chemoresistance is a central cause for the tumor management failure. Cancer cells disrupt
the redox homeostasis through reactive oxygen species (ROS) regulatory mechanisms …