α-and β-dystroglycan constitute a membrane-spanning complex that connects the
extracellular matrix to the cytoskeleton. Although a structural role for dystroglycan had been …

Laminins, one of the major functional components of basement membranes, are found
underlying endothelium, and encasing pericytes and smooth muscle cells in the vessel wall …

Mutations of different components of the dystrophin–glycoprotein complex (DGC) cause
muscular dystrophies that vary in terms of severity, age of onset, and selective involvement …

The dystrophin–glycoprotein complex (DGC) is a multisubunit complex that connects the
cytoskeleton of a muscle fiber to its surrounding extracellular matrix. Mutations in the DGC …

Dystroglycan is a central component of the dystrophin-glycoprotein complex (DGC), a
protein assembly that plays a critical role in a variety of muscular dystrophies. In order to …

Dystrophin is a 427 kDa sub-membrane cytoskeletal protein, associated with the inner
surface membrane and incorporated in a large macromolecular complex of proteins, the …

Congenital muscular dystrophies with hypoglycosylation of α-dystroglycan (α-DG) are a
heterogeneous group of disorders often associated with brain and eye defects in addition to …

Laminins are a family of multifunctional macromolecules, ubiquitous in basement
membranes, and represent the most abundant structural noncollagenous glycoproteins of …

Basement membranes are composed of ordered arrays of characteristic extracellular matrix
proteins, but little is known about the assembly of these structures in vivo. We have …

Collagen IV is a major structural component of all basal laminae (BLs). Six collagen IV alpha
chains are present in mammals; alpha 1 and alpha 2 (IV) are broadly expressed in embryos …