Trace amines are endogenous compounds classically regarded as comprising β-
phenylethyalmine, p-tyramine, tryptamine, p-octopamine, and some of their metabolites …

Trace amine-associated receptor 1 (TAAR1) has emerged as a promising therapeutic target
for neuropsychiatric disorders due to its ability to modulate monoaminergic and …

The discovery in 2001 of a G protein-coupled receptor family, subsequently termed trace
amine-associated receptors (TAAR), triggered a resurgence of interest in so-called trace …

Trace amines, a group of amines expressed at the nanomolar level in the mammalian brain,
can modulate monoamine transmission. The discovery of and the functional research on the …

The claustrum connects with a broad range of cortical areas including the prefrontal cortex
(PFC). However, the function of the claustrum (CLA) and its neural projections remains …

Background Comorbidity of anxiety disorders, stressor-and trauma-related disorders, and
substance use disorders is extremely common. Moreover, therapies that reduce pathological …

Introduction: The trace amines, endogenous amines closely related to the biogenic amine
neurotransmitters, have been known to exert physiological and neurological effects for …

There is a need for innovation with respect to therapeutics in psychiatry. Available evidence
indicates that the trace amine-associated receptor 1 (TAAR1) agonist SEP-363856 is …

Nicotine addiction and abuse remains a global health issue. To date, the fundamental
neurobiological mechanism of nicotine addiction remains incompletely understood. Trace …

Introduction Current antipsychotics are postsynaptic dopamine-2 (D2) receptor blockers,
which often, but not always, effectively improve acute psychotic symptoms and prevent …