One of the most challenging tasks in the development of protein pharmaceuticals is to deal
with physical and chemical instabilities of proteins. Protein instability is one of the major …

The accumulation of compatible solutes is a prerequisite for the adaptation of
microorganisms to osmotic stress imposed by salt or organic solutes. Two types of strategies …

Extremophilic microorganisms have adopted a variety of ingenious strategies for survival
under high or low temperature, extreme pressure, and drastic salt concentrations. A novel …

Referee: Dr. Ruth Nussinov, Saic Frederick, Bldg. 469. 469, Room 151, Frederick, MD
21702-1201 Hyperthermophilic organisms optimally grow close to the boiling point of water …

The availability of water is the most important prerequisite for life of any living cell, and
exposure of cells to hypersaline conditions always threatens the cells with a drastic loss of …

Highlights•Extremolytes protect extremophilic microbes from environmental stress.•They
enable multiple applications in cosmetics, food, and health industry.•Ectoine is the industrial …

The accumulation of organic solutes is a prerequisite for osmotic adjustment of all
microorganisms. Thermophilic and hyperthermophilic organisms generally accumulate very …

Prokaryotes inhabiting in the deep sea vent ecosystem will thus experience harsh conditions
of temperature, pH, salinity or high hydrostatic pressure (HHP) stress. Among the fifty-two …

The ability to adapt to ffuctuations in external osmotic pressure (osmoadaptation) and the
development of specific mechanisms to achieve this (osmoregulation) are fundamental to …

The protection of mannosylglycerate, at 0.5 M concentration, against heat inactivation of the
model enzyme lactate dehydrogenase (LDH) was compared to that exerted by other …