Many recent advances have emerged in the telomere and telomerase fields. This Timeline
article highlights the key advances that have expanded our views on the mechanistic …

Telomerase, a eukaryotic ribonucleoprotein (RNP) complex, contains both an essential RNA
and a protein reverse transcriptase subunit. By reverse transcription, the telomerase RNP …

Cellular senescence can be triggered by telomere shortening as well as a variety of stresses
and signaling imbalances. We used multiparameter single-cell detection methods to …

We report cytologic and genetic data indicating that telomere dysfunction induces a DNA
damage response in mammalian cells. Dysfunctional, uncapped telomeres, created through …

The ATM protein kinase is a primary activator of the cellular response to DNA double‐strand
breaks (DSBs). In response to DSBs, ATM is activated and phosphorylates key players in …

Human bone marrow stromal cells (hMSCs) were stably transduced by a retroviral vector
containing the gene for the catalytic subunit of human telomerase (hTERT). Transduced …

The discovery of telomeres dates back to the early 20th century. In humans, telomeres are
heterochromatic structures with tandem DNA repeats of 5′‐TTAGGG‐3′ at the …

The proliferative capacity of human cells is regulated by telomerase, an enzyme uniquely
specialised for telomeric DNA synthesis. The critical role of telomerase activation in tumour …

Telomeres are dynamic nucleoprotein-DNA structures that cap and protect linear
chromosome ends. Several monogenic inherited diseases that display features of human …

The recognition and signaling of DNA double strand breaks involves the participation of
multiple proteins, including the protein kinase ATM (mutated in ataxia-telangiectasia). ATM …