Cellular and molecular mechanisms of kidney fibrosis
Renal fibrosis is the final pathological process common to any ongoing, chronic kidney
injury or maladaptive repair. It is considered as the underlying pathological process of …
injury or maladaptive repair. It is considered as the underlying pathological process of …
The angiotensin AT2 receptor: from a binding site to a novel therapeutic target
UM Steckelings, RE Widdop, ED Sturrock… - Pharmacological …, 2022 - Elsevier
Discovered more than 30 years ago, the angiotensin AT 2 receptor (AT 2 R) has evolved
from a binding site with unknown function to a firmly established major effector within the …
from a binding site with unknown function to a firmly established major effector within the …
[HTML][HTML] Physiology, renin angiotensin system
JH Fountain, J Kaur, SL Lappin - 2017 - europepmc.org
The renin-angiotensin-aldosterone system (RAAS) is a critical regulator of blood volume,
electrolyte balance, and systemic vascular resistance. While the baroreceptor reflex …
electrolyte balance, and systemic vascular resistance. While the baroreceptor reflex …
Causes and pathogenesis of focal segmental glomerulosclerosis
AB Fogo - Nature Reviews Nephrology, 2015 - nature.com
Focal segmental glomerulosclerosis (FSGS) describes both a common lesion in progressive
kidney disease, and a disease characterized by marked proteinuria and podocyte injury …
kidney disease, and a disease characterized by marked proteinuria and podocyte injury …
mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice
Diabetic nephropathy (DN) is among the most lethal complications that occur in type 1 and
type 2 diabetics. Podocyte dysfunction is postulated to be a critical event associated with …
type 2 diabetics. Podocyte dysfunction is postulated to be a critical event associated with …
Renal interstitial fibrosis: mechanisms and evaluation
AB Farris, RB Colvin - Current opinion in nephrology and …, 2012 - journals.lww.com
Renal interstitial fibrosis: mechanisms and evaluation : Current Opinion in Nephrology and
Hypertension Renal interstitial fibrosis: mechanisms and evaluation : Current Opinion in …
Hypertension Renal interstitial fibrosis: mechanisms and evaluation : Current Opinion in …
Diabetic nephropathy: novel molecular mechanisms and therapeutic targets
C Zoja, C Xinaris, D Macconi - Frontiers in pharmacology, 2020 - frontiersin.org
Diabetic nephropathy (DN) is one of the major microvascular complications of diabetes
mellitus and the leading cause of end-stage kidney disease. The standard treatments for …
mellitus and the leading cause of end-stage kidney disease. The standard treatments for …
Inhibition of angiotensin-converting enzyme ameliorates renal fibrosis by mitigating DPP-4 level and restoring antifibrotic MicroRNAs
SP Srivastava, JE Goodwin, K Kanasaki, D Koya - Genes, 2020 - mdpi.com
Two class of drugs 1) angiotensin-converting enzyme inhibitors (ACEis) and 2) angiotensin
II receptor blockers (ARBs) are well-known conventional drugs that can retard the …
II receptor blockers (ARBs) are well-known conventional drugs that can retard the …
Angiotensin AT2 Receptor Stimulation Inhibits Early Renal Inflammation in Renovascular Hypertension
LC Matavelli, J Huang, HM Siragy - Hypertension, 2011 - Am Heart Assoc
Angiotensin II type 2 receptor (AT2R) counteracts most effects of angiotensin II type 1
receptor (AT1R). We hypothesized that direct AT2R stimulation reduces renal production of …
receptor (AT1R). We hypothesized that direct AT2R stimulation reduces renal production of …
[HTML][HTML] The non-classical renin-angiotensin system and renal function
MC Chappell - Comprehensive Physiology, 2012 - ncbi.nlm.nih.gov
The renin-angiotensin-system (RAS) constitutes one of the most important hormonal
systems in the physiological regulation of blood pressure through renal and non-renal …
systems in the physiological regulation of blood pressure through renal and non-renal …