Integrins are transmembrane receptors that possess distinct ligand-binding specificities in
the extracellular domain and signaling properties in the cytoplasmic domain. While most …

Macropinocytosis has long been known as a primary method for cellular intake of fluid-
phase and membrane-bound bulk cargo. This review seeks to re-examine the latest studies …

Macropinocytosis is a widely-observed and evolutionarily-conserved endocytic process
found in the eukaryotic cells. In comparison to other endocytic routes, macropinocytosis …

Mesoporous silica nanoparticles (MSNs) are considered as promising next-generation
nanocarriers for health-related applications. However, their effectiveness mostly relies on …

Brain delivery of nanoparticles and macromolecular drugs depends on blood-brain barrier
(BBB)-permeable carriers. In this study, we searched for cyclic heptapeptides facilitating …

Extensive investigations have been carried out for evaluating the toxicology of various
nanomaterials (eg, carbon-and metal-based nanomaterials), which offer invaluable …

Silica nanoparticles (SiNPs) are generally regarded as safe and may represent an attractive
carrier platform for nanomedical applications when loaded with biopharmaceuticals. Surface …

Viruses from the family Hantaviridae are encountered as emerging pathogens causing two
life-threatening human zoonoses: hemorrhagic fever with renal syndrome (HFRS) and …

Methodology to enhance intestinal absorption of macromolecular drugs is an important
challenge for developing next-generation biomedicines. So far, various cationic cell …

Small interfering ribonucleic acid (siRNA) has the potential to revolutionize therapeutics
since it can knockdown very efficiently the target protein. It is starting to be widely used to …