Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine
The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
Serotonin and prefrontal cortex function: neurons, networks, and circuits
MV Puig, AT Gulledge - Molecular neurobiology, 2011 - Springer
Higher-order executive tasks such as learning, working memory, and behavioral flexibility
depend on the prefrontal cortex (PFC), the brain region most elaborated in primates. The …
depend on the prefrontal cortex (PFC), the brain region most elaborated in primates. The …
Mechanisms of persistent activity in cortical circuits: possible neural substrates for working memory
J Zylberberg, BW Strowbridge - Annual review of neuroscience, 2017 - annualreviews.org
A commonly observed neural correlate of working memory is firing that persists after the
triggering stimulus disappears. Substantial effort has been devoted to understanding the …
triggering stimulus disappears. Substantial effort has been devoted to understanding the …
Htr2a Gene and 5-HT2A Receptor Expression in the Cerebral Cortex Studied Using Genetically Modified Mice
ET Weber, R Andrade - Frontiers in neuroscience, 2010 - frontiersin.org
Serotonin receptors of the 5-HT2A subtype are robustly expressed in the cerebral cortex
where they have been implicated in the pathophysiology and therapeutics of mental …
where they have been implicated in the pathophysiology and therapeutics of mental …
Preferential localization of muscarinic M1 receptor on dendritic shaft and spine of cortical pyramidal cells and its anatomical evidence for volume transmission
M Yamasaki, M Matsui, M Watanabe - Journal of Neuroscience, 2010 - Soc Neuroscience
Acetylcholine (ACh) plays important roles for higher brain functions, including arousal,
attention, and cognition. These effects are mediated largely by muscarinic acetylcholine …
attention, and cognition. These effects are mediated largely by muscarinic acetylcholine …
Muscarinic signaling in the brain
A Thiele - Annual review of neuroscience, 2013 - annualreviews.org
Muscarinic signaling affects attention, action selection, learning, and memory through
multiple signaling cascades, which act at different timescales and which alter ion channels …
multiple signaling cascades, which act at different timescales and which alter ion channels …
Spatiotemporal specificity in cholinergic control of neocortical function
Highlights•Cholinergic actions with specific spatiotemporal patterns regulate cognition.•Both
nicotinic and muscarinic responses can be fast and precise.•Interneuron-specific cholinergic …
nicotinic and muscarinic responses can be fast and precise.•Interneuron-specific cholinergic …
Dynamic NHERF interaction with TRPC4/5 proteins is required for channel gating by diacylglycerol
U Storch, AL Forst, F Pardatscher… - Proceedings of the …, 2017 - National Acad Sciences
The activation mechanism of the classical transient receptor potential channels TRPC4 and-
5 via the Gq/11 protein-phospholipase C (PLC) signaling pathway has remained elusive so …
5 via the Gq/11 protein-phospholipase C (PLC) signaling pathway has remained elusive so …
Norepinephrine drives persistent activity in prefrontal cortex via synergistic α1 and α2 adrenoceptors
Z Zhang, S Cordeiro Matos, S Jego, A Adamantidis… - PloS one, 2013 - journals.plos.org
Optimal norepinephrine levels in the prefrontal cortex (PFC) increase delay-related firing
and enhance working memory, whereas stress-related or pathologically high levels of …
and enhance working memory, whereas stress-related or pathologically high levels of …
TRPs in the brain
The Transient receptor potential (TRP) family of cation channels is a large protein family,
which is mainly structurally uniform. Proteins consist typically of six transmembrane domains …
which is mainly structurally uniform. Proteins consist typically of six transmembrane domains …