Synapses are intercellular junctions specialized for fast, point-to-point information transfer
from a presynaptic neuron to a postsynaptic cell. At a synapse, a presynaptic terminal …

Bioorthogonal cleavage chemistry has been rapidly emerging as a powerful tool for
manipulation and gain-of-function studies of biomolecules in living systems. While the initial …

To understand brain function, it is essential that we discover how cellular signaling specifies
normal and pathological brain function. In this regard, chemogenetic technologies represent …

INTRODUCTION Protein kinases mediate many cell signaling processes. Central to their
physiological function is the regulation of their binding and enzymatic activities, which is …

Accurate control of gene expression is essential for normal development and dysregulation
of transcription underpins cancer onset and progression. Similar to cell cycle regulation …

Metabolism research is undergoing a renaissance because many diseases are increasingly
recognized as being characterized by perturbations in intracellular metabolic regulation …

Macromolecular crowding has a profound impact on reaction rates and the physical
properties of the cell interior, but the mechanisms that regulate crowding are poorly …

Learning and memory are thought to require hippocampal long-term potentiation (LTP), and
one of the few central dogmas of molecular neuroscience that has stood undisputed for …

S phase and mitotic onset are brought about by the action of multiple different cyclin-CDK
complexes. However, it has been suggested that changes in the total level of CDK kinase …

Cellular function can be controlled through the gene expression program, but often protein
post-translational modifications (PTMs) provide a more precise and elegant mechanism. Key …