Neuronal cell death occurs extensively during development and pathology, where it is
especially important because of the limited capacity of adult neurons to proliferate or be …

Background & Objective: Traumatic Brain Injury (TBI) is one of the major causes of mortality
and morbidity worldwide. It represents mild, moderate and severe effects of physical assault …

Oxidative stress is a common denominator in the pathology of neurodegenerative disorders
such as Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral …

Traumatic brain injury (TBI) represents a major cause of death and disability in developed
countries. Brain injuries are highly heterogeneous and can also trigger other neurological …

Background Nuclear factor (erythroid-derived 2) factor 2 (Nrf2) is a crucial transcription factor
mediating protection against oxidants. Nrf2 is negatively regulated by cytoplasmic Kelch-like …

DJ-1 protein has multiple specific mechanisms to protect dopaminergic neurons against
neurodegeneration in Parkinson's disease. Wild type DJ-1 can acts as oxidative stress …

Traumatic brain injury (TBI) elicits an inflammatory response in the central nervous system
(CNS) that involves both resident and peripheral immune cells. Neuroinflammation can …

Recent clinical studies indicate that traumatic brain injury (TBI) produces chronic and
progressive neurodegenerative changes leading to late neurologic dysfunction, but little is …

Activated microglia and macrophages exert dual beneficial and detrimental roles after
central nervous system injury, which are thought to be due to their polarization along a …

MicroRNAs (miRNAs) are small noncoding RNAs that broadly affect cellular and
physiological function in all multicellular organisms. Here, the role of miRNAs in …