Narcolepsy is a rare brain disorder that reflects a selective loss or dysfunction of orexin (also
known as hypocretin) neurons of the lateral hypothalamus. Narcolepsy type 1 (NT1) is …

Narcolepsy is the most common neurological cause of chronic sleepiness. The discovery
about 20 years ago that narcolepsy is caused by selective loss of the neurons producing …

Biological clocks are genetically encoded oscillators that allow organisms to anticipate
changes in the light–dark environment that are tied to the rotation of Earth. Clocks enhance …

The hypocretins (Hcrts), also known as orexins, are two neuropeptides produced exclusively
in the lateral hypothalamus. They act on two specific receptors that are widely distributed …

Orexins, also known as hypocretins, are two neuropeptides secreted from orexin-containing
neurons, mainly in the lateral hypothalamus (LH). Orexins orchestrate their effects by …

Context Narcolepsy, a neurological disorder affecting 1 in 2000 individuals, is associated
with HLA-DQB1* 0602 and low cerebrospinal fluid (CSF) hypocretin (orexin) levels …

Mammals respond to reduced food availability by becoming more wakeful and active, yet the
central pathways regulating arousal and instinctual motor programs (such as food seeking) …

Narcolepsy with cataplexy is a disabling sleep disorder affecting 0· 02% of adults worldwide.
It is characterised by severe, irresistible daytime sleepiness and sudden loss of muscle tone …

Narcolepsy, a chronic neurologic condition resulting from dysregulation of the sleep–wake
cycle, usually has an onset at an early age. However, a long delay until diagnosis has been …

Early diagnosis of neurodegenerative disorders such as Alzheimer's (AD) or Parkinson's
disease (PD) is needed to slow down or halt the disease at the earliest stage. Cerebrospinal …