Oxidative stress is a component of many diseases, including atherosclerosis, chronic
obstructive pulmonary disease, Alzheimer disease and cancer. Although numerous small …

Vitamin C is an essential micronutrient for humans, with pleiotropic functions related to its
ability to donate electrons. It is a potent antioxidant and a cofactor for a family of biosynthetic …

Background Our recent meta-analysis indicated that vitamin C may shorten the length of ICU
stay and the duration of mechanical ventilation. Here we analyze modification of the vitamin …

Since the discovery of vitamin C, the number of its known biological functions is continually
expanding. Both the names ascorbic acid and vitamin C reflect its antiscorbutic properties …

The mechanistic properties of two dietary antioxidants that are required by humans, vitamins
C and E, are discussed relative to their biological effects. Vitamin C (ascorbic acid) is an …

Multiple reactive oxygen/nitrogen species induce oxidative stress. Mammals have evolved
with an elaborate defense network against oxidative stress, in which multiple antioxidant …

Vitamin E is a group of isoprenoid chromanols with different biological activities. It comprises
eight oil‐soluble compounds: four tocopherols, namely, α‐, β‐, γ‐, and δ‐tocopherols; and …

Knee osteoarthritis (KOA) is one of the most common degenerative diseases, and its core
feature is the degeneration and damage of articular cartilage. The cartilage degeneration of …

All of the naturally occurring vitamin E forms, as well as those of synthetic all-rac-α-
tocopherol, have relatively similar antioxidant properties, so why does the body prefer α …

Lipid peroxidation (LPO) has been shown to induce disturbance of membrane organization
and functional loss and modification of proteins and DNA bases, and it has been implicated …