Cyclosporine A (CsA) is a widely used immunosuppressive agent that greatly reduces the
rates of kidney-, heart-, and liver-transplant rejection. However, CsA nephrotoxicity is a …

Endothelin (ET) is found to be increased in kidney disease secondary to hyperglycaemia,
hypertension, acidosis, and the presence of insulin or proinflammatory cytokines. In this …

Cyclosporin A (CsA) induced nephrotoxicity ie, renal fibrosis is a critical clinical problem in
renal transplant patients, in which chronic inflammatory response is the major cause …

The clinical use of cyclosporin A (CsA) has led to significant advances and achievements in
the field of transplantation and immune diseases. However, the nephrotoxicity of CsA is a …

Background: Cyclosporine A (CsA) is widely used for organ transplantation and autoimmune
disorders. However, CsA nephrotoxicity is a serious side effect that limits the clinical use of …

Arsenic exposure is well documented to cause serious health hazards, such as
cardiovascular abnormalities, neurotoxicity and nephrotoxicity. In the present study, we …

The immunosuppressant cyclosporine A (CSA) has been linked to serious renal toxic effects.
Although 2-methoxyestradiol (2ME) possesses a wide range of pharmacological abilities, it …

The recent study delves into the role of both liraglutide and/or resveratrol on the
nephropathic affection in rats treated with cyclosporine A (CsA). Rats were intoxicated with …

G protein-coupled receptors (GPCRs) play pivotal roles in regulation of cardiovascular
homeostasis across all vertebrate species, including humans. In terms of normal cellular …

Cyclosporine A (CsA) is a strong immunosuppressive drug, but its use is frequently
accompanied by severe renal toxicity. The potential renoprotective effect of Thymoquinone …