To overcome numerous health disorders, heterocyclic structures of synthetic or natural origin
are utilized, and notably, the emergence of various side effects of existing drugs used for …

Microbial natural products (NPs) are a major source of pharmacological agents. Most NPs
are synthesized from specific biosynthetic gene clusters (BGCs). With the rapid increase of …

Quorum sensing (QS) is a communication system used by bacteria to coordinate a wide
panel of biological functions in a cell density-dependent manner. The Gram-negative …

Streptomyces lividans is a suitable host for the heterologous expression of biosynthetic gene
clusters (BGCs) from actinomycetes to discover “cryptic” secondary metabolites. To improve …

Plant‐specialized metabolism is complex, with frequent examples of highly branched
biosynthetic pathways, and shared chemical intermediates. As such, many plant‐specialized …

Including pulses in wheat-based cropping systems in semiarid regions may be a strategy for
sustainably intensifying crop production. However, the impact of an increase in the …

Background Fatty liver hemorrhage syndrome (FLHS) becomes one of the most major
factors resulting in the laying hen death for caged egg production. This study aimed to …

Biocatalysis is becoming an indispensable tool in organic synthesis due to high enzymatic
catalytic efficiency as well as exquisite chemo-and stereoselectivity. Some biocatalysts …

Two new cyclodipeptide (CDP) derivatives (1–2) and another seven known cyclodipeptides
(3–9) were isolated from Streptomyces 26D9-414 by the genome mining approach …

Mechanisms of lung squamous cell carcinoma (LSCC) development are poorly understood.
Here, we report that JNK1/2 activities attenuate Lkb1-deficiency-driven LSCC initiation and …