Plasminogen is an abundant plasma protein that exists in various zymogenic forms.
Plasmin, the proteolytically active form of plasminogen, is known for its essential role in …

Tranexamic acid (TXA) is a popular antifibrinolytic drug widely used in hemorrhagic trauma
patients and cardiovascular, orthopedic, and gynecological surgical patients. TXA binds …

Background Women are less likely than men to receive some emergency treatments. This
study examines whether the effect of tranexamic acid (TXA) on mortality in trauma patients …

Traumatic brain injury (TBI) is the leading cause of disability and death, and the social
burden of mortality and morbidity caused by TBI is significant. Under the influence of …

BACKGROUND Tranexamic acid (TXA) given early, but not late, after traumatic brain injury
(TBI) appears to improve survival. This may be partly related to TXA-driven profibrinolysis …

Peri-operative bleeding is a major cause of morbidity and mortality in patients undergoing
surgery. Tranexamic acid, an antifibrinolytic agent, is effective for prevention and treatment …

There is emerging evidence of inequalities in healthcare provision between women and
men. Trauma care is no exception with a number of studies indicating lower levels of …

Background and Purpose Traumatic brain injury (TBI) remains a leading cause of mortality
and morbidity in young adults. The role of iron in potentiating neurodegeneration following …

BACKGROUND Early but not late tranexamic acid (TXA) after TBI preserves blood-brain-
barrier integrity, but it is unclear if and how dose timing affects cognitive recovery beyond …

Fibrinolysis is the process of the fibrin–platelet clot dissolution initiated after bleeding has
been stopped. It is regulated by a cascade of proteolytic enzymes with plasmin at its core. In …