The centenary of insulin discovery represents an important opportunity to transform diabetes
from a fatal diagnosis into a medically manageable chronic condition. Insulin is a key …

Obesity is a global epidemic characterized by energy disequilibrium, metabolic disorder, fat
mass development, and chronic low-grade inflammation, which significantly affects the …

Public health globally faces significant risks from conditions like acute respiratory distress
syndrome (ARDS), chronic obstructive pulmonary disease (COPD), and various …

Pancreatic β-cell compensation is a major mechanism in delaying T2DM progression. Here
we report the abnormal high expression of circGlis3 in islets of male mice with obesity and …

Long non-coding RNAs (lncRNAs) are RNAs with a length of no less than 200 nucleotides
that are not translated into proteins. Accumulating evidence indicates that lncRNAs are …

Diabetic macroangiopathy is a leading cause of diabetes-related mortality worldwide. Both
genetic and environmental factors, through a multitude of underlying molecular …

Obesity and chronic low-grade inflammation, often occurring together, significantly
contribute to severe metabolic and inflammatory conditions like type 2 diabetes (T2D) …

Pineal melatonin and the cortisol awakening response (CAR) are integral aspects of the
circadian rhythm. Pineal melatonin release during sleep is proposed to optimize …

The β-cells within the pancreas play a pivotal role in insulin production and secretion,
responding to fluctuations in blood glucose levels. However, factors like obesity, dietary …

Type 2 diabetes mellitus (T2DM), a high-incidence chronic metabolic disorder, has emerged
as a global health issue, where most patients need lifelong medication. Gaining insights into …