The liver is a central organ in the human body, coordinating several key metabolic roles. The
structure of the liver which consists of the distinctive arrangement of hepatocytes, hepatic …

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer mortality,
accounting for almost 90% of total liver cancer burden. Surgical resection followed by …

Background & Aims Proton beam radiotherapy (PBT) has recently been applied to treat
hepatocellular carcinoma (HCC); however, there is no randomized controlled trial-based …

Doxorubicin (DOX)-induced toxicity and resistance are major obstacles in chemotherapeutic
approaches. Despite effective in the treatment of numerous malignancies, some clinicians …

Background Doxorubicin is one of the most commonly prescribed and time-tested anticancer
drugs. Although being considered as a first line drug in different types of cancers, the two …

Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Intense
efforts have been made to elucidate the pathogeny, but the molecular mechanisms of HCC …

Hepatocellular carcinoma (HCC) is a devastating disease worldwide. Though many efforts
have been made to elucidate the process of HCC, its molecular mechanisms of …

Hepatocellular carcinoma, one of the most common solid tumors worldwide, is poorly
responsive to available chemotherapeutic approaches. While systemic chemotherapy is of …

Hepatocellular carcinoma (HCC) is one of the most common and lethal types of cancer. This
study aimed to identify the expression regulatory network and a prognostic signature of …

Abstract Topoisomerase IIα (TOP2A) plays an oncogenic role in multiple tumor types.
However, no pan-cancer analysis about the function and the upstream molecular …