Multivalent proteins and nucleic acids, collectively referred to as multivalent associative
biomacromolecules, provide the driving forces for the formation and compositional …

Biomolecular condensate formation has been implicated in a host of biological processes
and has found relevance in biology and disease. Understanding the physical principles and …

Prion-like low-complexity domains (PLCDs) are involved in the formation and regulation of
distinct biomolecular condensates that form via phase separation coupled to percolation …

Protein liquid–liquid phase separation can lead to disease-related amyloid fibril formation.
The mechanisms of conversion of monomeric protein into condensate droplets and of the …

Antimicrobial peptides (AMPs), which combat bacterial infections by disrupting the bacterial
cell membrane or interacting with intracellular targets, are naturally produced by a number of …

Cellular matter can be organized into compositionally distinct biomolecular condensates.
For example, in Ashbya gossypii, the RNA-binding protein Whi3 forms distinct condensates …

It is now generally accepted that macromolecules do not act in isolation but “live” in a
crowded environment, that is, an environment populated by numerous different molecules …

Biomolecular condensates constitute a newly recognized form of spatial organization in
living cells. Although many condensates are believed to form as a result of phase …

Biomolecular condensation processes are increasingly recognized as a fundamental
mechanism that living cells use to organize biomolecules in time and space. These …

Phase separation inside mammalian cells regulates the formation of the biomolecular
condensates that are related to gene expression, signalling, development and disease …