The epidemiology of Parkinson's disease: risk factors and prevention
A Ascherio, MA Schwarzschild - The Lancet Neurology, 2016 - thelancet.com
Since 2006, several longitudinal studies have assessed environmental or behavioural
factors that seem to modify the risk of developing Parkinson's disease. Increased risk of …
factors that seem to modify the risk of developing Parkinson's disease. Increased risk of …
Disease-modifying therapies in amyotrophic lateral sclerosis
A Chiò, L Mazzini, G Mora - Neuropharmacology, 2020 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder of adult life, causing
weakness and wasting of voluntary muscles, associated in about 50% of cases with a …
weakness and wasting of voluntary muscles, associated in about 50% of cases with a …
[HTML][HTML] The British Society for Rheumatology guideline for the management of gout
M Hui, A Carr, S Cameron, G Davenport… - …, 2017 - academic.oup.com
Gout is the most common cause of inflammatory arthritis worldwide. In UK general practice,
the overall prevalence has increased from 1.4% in 1999 to 2.49% in 2012 [1], despite the …
the overall prevalence has increased from 1.4% in 1999 to 2.49% in 2012 [1], despite the …
The PRO-ACT database: design, initial analyses, and predictive features
Objective: To pool data from completed amyotrophic lateral sclerosis (ALS) clinical trials and
create an open-access resource that enables greater understanding of the phenotype and …
create an open-access resource that enables greater understanding of the phenotype and …
[HTML][HTML] Biomarkers in motor neuron disease: a state of the art review
NS Verber, SR Shepheard, M Sassani… - Frontiers in …, 2019 - frontiersin.org
Motor neuron disease can be viewed as an umbrella term describing a heterogeneous
group of conditions, all of which are relentlessly progressive and ultimately fatal. The …
group of conditions, all of which are relentlessly progressive and ultimately fatal. The …
[HTML][HTML] The influence of serum uric acid on the brain and cognitive dysfunction
NR Mijailovic, K Vesic, MM Borovcanin - Frontiers in Psychiatry, 2022 - frontiersin.org
Uric acid is commonly known for its bad reputation. However, it has been shown that uric
acid may be actively involved in neurotoxicity and/or neuroprotection. These effects could be …
acid may be actively involved in neurotoxicity and/or neuroprotection. These effects could be …
Role of uric acid metabolism‐related inflammation in the pathogenesis of metabolic syndrome components such as atherosclerosis and nonalcoholic steatohepatitis
A Kushiyama, Y Nakatsu, Y Matsunaga… - Mediators of …, 2016 - Wiley Online Library
Uric acid (UA) is the end product of purine metabolism and can reportedly act as an
antioxidant. However, recently, numerous clinical and basic research approaches have …
antioxidant. However, recently, numerous clinical and basic research approaches have …
[HTML][HTML] A double-edged sword: uric acid and neurological disorders
Uric Acid (UA), historically considered as a waste of cellular metabolism, has now received
increasing attention because it was found to directly participate in the pathogenesis of many …
increasing attention because it was found to directly participate in the pathogenesis of many …
Amyotrophic lateral sclerosis outcome measures and the role of albumin and creatinine: a population-based study
Importance There is an urgent need to identify reliable biomarkers of amyotrophic lateral
sclerosis (ALS) progression for clinical practice and pharmacological trials. Objectives To …
sclerosis (ALS) progression for clinical practice and pharmacological trials. Objectives To …
Drug discovery and amyotrophic lateral sclerosis: Emerging challenges and therapeutic opportunities
Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of upper and lower
motor neurons (MNs) leading to paralysis and, ultimately, death by respiratory failure 3–5 …
motor neurons (MNs) leading to paralysis and, ultimately, death by respiratory failure 3–5 …