Nonischemic dilated cardiomyopathy (DCM) often has a genetic pathogenesis. Because of
the large number of genes and alleles attributed to DCM, comprehensive genetic testing …

Long QT syndrome (LQTS) is an inherited primary arrhythmia syndrome that may present
with malignant arrhythmia and, rarely, risk of sudden death. The clinical symptoms include …

Background—Human pluripotent stem cell–derived cardiomyocytes (hPSC-CMs)
monolayers generated to date display an immature embryonic-like functional and structural …

Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are a promising
tool for drug testing and modelling genetic disorders. Abnormally low upstroke velocity is a …

Schwartz et al LQTS: From Genetics to Management 869 transmembrane portion of the K+
channel with a mild dominant-negative functional effect; in these patients, we demonstrated …

Background—Pluripotent stem cells (PSCs) offer a new paradigm for modeling genetic
cardiac diseases, but it is unclear whether mouse and human PSCs can truly model both …

Human heart failure due to myocardial infarction is a major health concern. The paucity of
organs for transplantation limits curative approaches for the diseased and failing adult heart …

Over the last two decades, an increasing number of SCN5A mutations have been described
in patients with long QT syndrome type 3 (LQT3), Brugada syndrome,(progressive) …

Background Type 3 long QT syndrome (LQT3) is the third most common form of LQT
syndrome and is characterized by QT-interval prolongation resulting from a gain-of-function …

With the discovery of induced pluripotent stem (iPS) cells, it is now possible to convert
differentiated somatic cells into multipotent stem cells that have the capacity to generate all …