Oxidative stress and inflammation are two critical pathological processes of cerebral
ischemia-reperfusion injury. Myeloperoxidase (MPO) is a critical inflammatory enzyme and …

Microglia are the resident immune cells of the central nervous system that exert diverse roles
in the pathogenesis of ischemic stroke. During the past decades, microglial polarization and …

Neutrophils are rapidly recruited in response to local tissue infection or inflammation. Stroke
triggers a strong inflammatory reaction but the relevance of neutrophils in the ischemic brain …

Background—Although lymphocyte recruitment and activation are associated with cerebral
ischemia-reperfusion (I/R) injury, the contributions of specific lymphocyte subpopulations …

Current knowledge regarding the pathophysiology of cerebral ischemia and brain trauma
indicates that similar mechanisms contribute to loss of cellular integrity and tissue …

Contrary to previous dogmas, it is now well established that brain cells can produce
cytokines and chemokines, and can express adhesion molecules that enable an in situ …

Inflammation plays a critical role in mediating brain injury induced by neonatal hypoxic
ischemic encephalopathy (HIE). The mechanisms underlying inflammatory responses to …

Oxidative stress has been implicated as playing a role in neurodegenerative disorders, such
as ischemic stroke, Alzheimer's, Huntington's, and Parkinson's disease. Persuasive …

Ischemic stroke is a leading cause of death and disability in developed countries. Yet, in
spite of substantial research and development efforts, no specific therapy for stroke is …

Neuronal injury from ischemic stroke is aggravated by invading peripheral immune cells.
Early infiltrates of neutrophil granulocytes and T-cells influence the outcome of stroke. So far …