Synaptic dysfunction and altered calcium homeostasis in the brain is common to many
neurodegenerative disorders. Among these, Huntington disease (HD), which is inherited in …

The endoplasmic reticulum is the main intracellular Ca 2+ store for Ca 2+ release during cell
signaling. There are different strategies to avoid ER Ca 2+ depletion. Release channels …

The rising interest in Kv7 modulators originates from their ability to evoke fundamental
electrophysiological perturbations in a tissue-specific manner. A large number of therapeutic …

In airway smooth muscle, the intracellular basal Ca2+ concentration [b (Ca2+) i] must be
tightly regulated by several mechanisms in order to maintain a proper airway patency. The b …

Ryanodine receptors (RyRs) are calcium channels located on the endo (sarco) plasmic
reticulum of muscle cells and neurons. They regulate the release of stored intracellular …

Progressive neuronal demise is a key contributor to the key pathogenic event implicated in
many different neurodegenerative disorders (NDDs). There are several therapeutic …

Reactive oxygen species induce neuronal cell death. However, the detailed mechanisms of
cell death have not yet been elucidated. Previously, we reported neurite degeneration …

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a potentially lethal
disease, whose characteristic ventricular tachycardias are adrenergic-dependent. Although …

Alzheimer's disease (AD) is the leading cause of dementia and is incurable. The widely
accepted amyloid hypothesis failed to produce efficient clinical therapies. In contrast, there is …

Abstract Background Cytosolic Ca2+ plays vital roles in myogenesis and muscle
development. As a major Ca2+ release channel of endoplasmic reticulum (ER), ryanodine …