Bidirectional airflow in lung airway-on-a-chip with matrix-derived membrane elicits epithelial glycocalyx formation

S Park, J Newton, T Hidjir, EWK Young - Lab on a Chip, 2023 - pubs.rsc.org
Organ-on-a-chip systems are rapidly advancing as a viable alternative to existing
experimental models in respiratory research. To date, however, epithelial cell cultures within …

Hybrid Biofabrication of Heterogeneous 3D Constructs Using Low-Viscosity Bioinks

SJ Kim, G Lee, JK Park - ACS Applied Materials & Interfaces, 2023 - ACS Publications
The application of cytocompatible hydrogels supporting extensive cellular activities to three-
dimensional (3D) bioprinting is crucial for recreating complex physiological environments …

Interrogating Matrix Stiffness and Metabolomics in Pancreatic Ductal Carcinoma Using an Openable Microfluidic Tumor-on-a-Chip

MD Mohan, N Latifi, R Flick, CA Simmons… - … Applied Materials & …, 2024 - ACS Publications
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense fibrotic stroma that
contributes to aggressive tumor biology and therapeutic resistance. Current in vitro PDAC …

Tunable In Situ Synthesis of Ultrathin Extracellular Matrix‐Derived Membranes in Organ‐on‐a‐Chip Devices

JD Newton, Y Song, S Park… - Advanced …, 2024 - Wiley Online Library
Thin cell culture membranes in organ‐on‐a‐chip (OOC) devices are used to model a wide
range of thin tissues. While early and most current platforms use microporous or fibrous …

Bioprinted Multi‐Composition Array Mimicking Tumor Microenvironments to Evaluate Drug Efficacy with Multivariable Analysis

G Lee, SJ Kim, JK Park - Advanced Healthcare Materials, 2024 - Wiley Online Library
Current organ‐on‐a‐chip technologies confront limitations in effectively recapitulating the
intricate in vivo microenvironments and accommodating diverse experimental conditions on …

Development and Characterization of a Human Model of Arteriovenous Malformations (AVM)-on-a-Chip

KE Soon - 2022 - search.proquest.com
Arteriovenous Malformation (AVM) is a vascular disease characterized by arteriovenous
shunting that results in dilated and fragile vessels. So far, there are no pharmaceutical …

Airflow-Mediated Microfluidic Device for Culturing Lung Airway Cells on a Suspended Hydrogel

S Park - 2023 - search.proquest.com
Airway epithelial cells (AECs) are a crucial component of the lung airways, responsible for
safeguarding our respiratory health by defending against inhaled particles like bacteria …

Flex and Flow: Microfluidic Platform for Application of Mechanical Stimulation in an Articular Joint-On-a-Chip

KK Cheung - 2022 - search.proquest.com
Osteoarthritis is a disease of the joint that greatly impacts the quality of life of 1 in 6
Canadians but has no known cure. In vitro models of the joint can enable advances in …