This review examines the generation of reactive oxygen species by mammalian
mitochondria, and the status of different sites of production in redox signaling and pathology …

Oxidative and reductive stress are dual dynamic phases experienced by the cells
undergoing adaptation towards endogenous or exogenous noxious stimulus. The former …

Excessive mitochondrial ROS production has been causally linked to the pathophysiology of
aging in the heart and other organs, and plays a deleterious role in several age-related …

Cardiomyocytes are one of the most mitochondria-rich cell types in the body, with∼ 30–40%
of the cell volume being composed of mitochondria. Mitochondria are well established as …

Mitochondria are essential for the development as well as maintenance of the myocardium,
the most energy consuming tissue in the human body. Mitochondria are not only a source of …

On the one hand, reactive oxygen species (ROS) are involved in the onset and progression
of a wide array of diseases. On the other hand, these are a part of signaling pathways …

Preconditioning, postconditioning, and remote conditioning of the myocardium enhance the
ability of the heart to withstand a prolonged ischemia/reperfusion insult and the potential to …

Mitochondrial dysfunction is a feature of type I and type II diabetes, but there is a lack of
consistency between reports and links to disease development. We aimed to investigate if …

Exercise produces oxidants from a variety of intracellular sources, including NADPH
oxidases (NOX) and mitochondria. Exercise-derived reactive oxygen species (ROS) are …

Aim: We hypothesize that both type-1 ryanodine receptor (RyR1) and IP3-receptor (IP3R)
calcium channels are necessary for the mitochondrial Ca2+ increase caused by membrane …