Neurotoxicity and developmental neurotoxicity are important issues of chemical hazard
assessment. Since the interpretation of animal data and their extrapolation to man is …

In recent years neurodevelopmental problems in children have increased at a rate that
suggests lifestyle factors and chemical exposures as likely contributors. When …

Multiple non-animal-based test methods have never been formally validated. In order to use
such new approach methods (NAMs) in a regulatory context, criteria to define their …

In this project we set up a human cell‐based DNTin vitro testing strategy that is based on test
methods with high readiness and data generated therefrom. The methods underwent afit‐for …

Impaired neuronal network function is a hallmark of neurodevelopmental and
neurodegenerative disorders such as autism, schizophrenia, and Alzheimer's disease and is …

There is a paucity of information concerning the developmental neurotoxicity (DNT) hazard
posed by industrial and environmental chemicals. New testing approaches will most likely …

Background In light of the vulnerability of the developing brain, mixture risk assessment
(MRA) for the evaluation of developmental neurotoxicity (DNT) should be implemented …

Organ-specific in vitro toxicity assays are often highly sensitive, but they lack specificity. We
evaluated here examples of assay features that can affect test specificity, and some general …

Predicting human safety risks of novel xenobiotics remains a major challenge, partly due to
the limited availability of human cells to evaluate tissue-specific toxicity. Recent progress in …

Due to their toxicity and persistence in the environment, brominated flame retardants (BFRs)
are being phased out of commercial use, leading to the increased use of alternative …