Glycosaminoglycans: key players in cancer cell biology and treatment
Glycosaminoglycans are natural heteropolysaccharides that are present in every
mammalian tissue. They are composed of repeating disaccharide units that consist of either …
mammalian tissue. They are composed of repeating disaccharide units that consist of either …
Proteoglycans in health and disease: novel roles for proteoglycans in malignancy and their pharmacological targeting
The expression of proteoglycans (PGs), essential macromolecules of the tumor
microenvironment, is markedly altered during malignant transformation and tumor …
microenvironment, is markedly altered during malignant transformation and tumor …
Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine‐rich proteoglycans
RV Iozzo, L Schaefer - The FEBS journal, 2010 - Wiley Online Library
The small leucine‐rich proteoglycans (SLRPs) are involved in many aspects of mammalian
biology, both in health and disease. They are now being recognized as key signaling …
biology, both in health and disease. They are now being recognized as key signaling …
Decorin is a novel antagonistic ligand of the Met receptor
Decorin, a member of the small leucine-rich proteoglycan gene family, impedes tumor cell
growth by down-regulating the epidermal growth factor receptor. Decorin has a complex …
growth by down-regulating the epidermal growth factor receptor. Decorin has a complex …
Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1α, vascular endothelial growth factor A, and induction of …
Decorin, a small leucine-rich proteoglycan, inhibits tumor growth by antagonizing multiple
receptor tyrosine kinases including EGFR and Met. Here, we investigated decorin during …
receptor tyrosine kinases including EGFR and Met. Here, we investigated decorin during …
The biology of small leucine-rich proteoglycans in bone pathophysiology
The class of small leucine-rich proteoglycans (SLRPs) is a family of homologous
proteoglycans harboring relatively small (36–42 kDa) protein cores compared with the larger …
proteoglycans harboring relatively small (36–42 kDa) protein cores compared with the larger …
Tumor microenvironment: Modulation by decorin and related molecules harboring leucine‐rich tandem motifs
Decorin, the prototype member of the small leucine‐rich proteoglycans, resides in the tumor
microenvironment and affects the biology of various types of cancer by downregulating the …
microenvironment and affects the biology of various types of cancer by downregulating the …
Role of the extracellular matrix in cancer‐associated epithelial to mesenchymal transition phenomenon
G Tzanakakis, RM Kavasi, K Voudouri… - Developmental …, 2018 - Wiley Online Library
The epithelial to mesenchymal transition (EMT) program is a crucial component in the
processes of morphogenesis and embryonic development. The transition of epithelial to …
processes of morphogenesis and embryonic development. The transition of epithelial to …
Decorin antagonizes Met receptor activity and down-regulates β-catenin and Myc levels
S Buraschi, N Pal, N Tyler-Rubinstein… - Journal of Biological …, 2010 - ASBMB
A theme emerging during the past few years is that members of the small leucine-rich
proteoglycan gene family affect cell growth by interacting with multiple receptor tyrosine …
proteoglycan gene family affect cell growth by interacting with multiple receptor tyrosine …
Fibronectin adsorption on electrospun synthetic vascular grafts attracts endothelial progenitor cells and promotes endothelialization in dynamic in vitro culture
R Daum, D Visser, C Wild, L Kutuzova, M Schneider… - Cells, 2020 - mdpi.com
Appropriate mechanical properties and fast endothelialization of synthetic grafts are key to
ensure long-term functionality of implants. We used a newly developed biostable …
ensure long-term functionality of implants. We used a newly developed biostable …