Combating mosquito-borne diseases using genetic control technologies

GH Wang, S Gamez, RR Raban, JM Marshall… - Nature …, 2021 - nature.com
Mosquito-borne diseases, such as dengue and malaria, pose significant global health
burdens. Unfortunately, current control methods based on insecticides and environmental …

The mosquito holobiont: fresh insight into mosquito-microbiota interactions

M Guégan, K Zouache, C Démichel, G Minard… - Microbiome, 2018 - Springer
The holobiont concept was first developed for coral ecosystems but has been extended to
multiple organisms, including plants and other animals. Studies on insect-associated …

Insect pathogenic fungus interacts with the gut microbiota to accelerate mosquito mortality

G Wei, Y Lai, G Wang, H Chen, F Li… - Proceedings of the …, 2017 - National Acad Sciences
The insect gut microbiota plays crucial roles in modulating the interactions between the host
and intestinal pathogens. Unlike viruses, bacteria, and parasites, which need to be ingested …

Microbiome interconnectedness throughout environments with major consequences for healthy people and a healthy planet

A Sessitsch, S Wakelin, M Schloter… - Microbiology and …, 2023 - Am Soc Microbiol
Microbiomes have highly important roles for ecosystem functioning and carry out key
functions that support planetary health, including nutrient cycling, climate regulation, and …

Mosquitoes host communities of bacteria that are essential for development but vary greatly between local habitats

KL Coon, MR Brown, MR Strand - Molecular ecology, 2016 - Wiley Online Library
Mosquitoes are insects of interest because several species vector disease‐causing
pathogens to humans and other vertebrates. We previously reported that mosquitoes from …

Paratransgenesis: a promising new strategy for mosquito vector control

ABB Wilke, MT Marrelli - Parasites & vectors, 2015 - Springer
The three main mosquito genera, Anopheles, Aedes and Culex, transmit respectively
malaria, dengue and lymphatic filariasis. Current mosquito control strategies have proved …

The microbiome modulates arbovirus transmission in mosquitoes

S Hegde, JL Rasgon, GL Hughes - Current opinion in virology, 2015 - Elsevier
Highlights•Complex interactions occur within the mosquito holobiome that profoundly alter
the phenotype of the host.•Bacteria can enhance or suppress arbovirus transmission in …

Symbionts and gene drive: two strategies to combat vector-borne disease

GH Wang, J Du, CY Chu, M Madhav, GL Hughes… - Trends in Genetics, 2022 - cell.com
Mosquitoes bring global health problems by transmitting parasites and viruses such as
malaria and dengue. Unfortunately, current insecticide-based control strategies are only …

Mosquito trilogy: microbiota, immunity and pathogens, and their implications for the control of disease transmission

P Gabrieli, S Caccia, I Varotto-Boccazzi… - Frontiers in …, 2021 - frontiersin.org
In mosquitoes, the interaction between the gut microbiota, the immune system, and the
pathogens that these insects transmit to humans and animals is regarded as a key …

Tick microbiome and pathogen acquisition altered by host blood meal

A Swei, JY Kwan - The ISME journal, 2017 - academic.oup.com
Lyme disease, a zoonotic disease, is the most prevalent vector-borne disease in the
Northern Hemisphere. Diversity of the vector (tick) microbiome can impact pathogen …