The mitotic spindle has a crucial role in ensuring the accurate segregation of chromosomes
into the two daughter cells during cell division, which is paramount for maintaining genome …

The microtubule-based spindle orchestrates chromosome segregation during cell division.
Following more than a century of study, many components and pathways contributing to …

Life depends on cell proliferation and the accurate segregation of chromosomes, which are
mediated by the microtubule (MT)-based mitotic spindle and∼ 200 essential MT-associated …

Accurate animal cell division requires precise coordination of changes in the structure of the
microtubule-based spindle and the actin-based cell cortex. Here, we use a series of …

Rapid and reductive cell divisions during embryogenesis require that intracellular structures
adapt to a wide range of cell sizes. The mitotic spindle presents a central example of this …

Nucleocytoplasmic transport is an essential process in eukaryotes. The molecular
mechanisms underlying nuclear transport that involve the nuclear transport receptor, small …

Kinesins are a diverse superfamily of microtubule-based motors that perform fundamental
roles in intracellular transport, cytoskeletal dynamics and cell division. These motors share a …

The mitotic spindle must function in cell types that vary greatly in size, and its dimensions
scale with the rapid, reductive cell divisions that accompany early stages of development …

The small GTPase Ran regulates the interaction of transport receptors with a number of
cellular cargo proteins. The high affinity binding of the GTP-bound form of Ran to import …

Early embryogenesis is accompanied by reductive cell divisions requiring that subcellular
structures adapt to a range of cell sizes. The interphase nucleus and mitotic spindle scale …