Reversing or slowing the aging process brings great promise to treat or prevent age‐related
disease, and targeting the hallmarks of aging is a strategy to achieve this. Epigenetics …

Long-standing efforts to identify the multifaceted roles of histone deacetylase inhibitors
(HDACis) have positioned these agents as promising drug candidates in combatting cancer …

Genetic variations along with epigenetic modifications of DNA are involved in colorectal
cancer (CRC) development and progression. CRC is the fourth leading cause of cancer …

Among the epigenetic changes, histone acetylation has been recognized as a fundamental
process that strongly affects gene expression regulation. Disrupt of this phenomenon has …

Neutrophils undergo a unique form of cell death that generates neutrophil extracellular traps
(NETs) that may help to neutralize invading pathogens and restore homeostasis. However …

T-cell lymphomas are a heterogeneous group of cancers with different pathogenesis and
poor prognosis. Histone deacetylases (HDACs) are epigenetic modifiers that modulate …

Cancer progression is strongly affected by epigenetic events in addition to genetic
modifications. One of the key elements in the epigenetic control of gene expression is …

Protein acetylation is a reversible post-translational modification, and is involved in many
biological processes in cells, such as transcriptional regulation, DNA damage repair, and …

Numerous environmental factors such as diet, alcohol use, stress, and environmental
chemicals are known to elicit epigenetic changes, leading to increased rates of cancers and …

Epigenetics is the study of heritable changes in gene expression or function without altering
the DNA sequence. Important factors are part of epigenetic events, such as methylation …