Background The objective of this article is to summarize the published literature concerning
the pharmacokinetics and pharmacodynamics of oral anticoagulant drugs that are currently …

Background High-quality anticoagulation management is required to keep these narrow
therapeutic index medications as effective and safe as possible. This article focuses on the …

ContextDevelopers of health care software have attributed improvements in patient care to
these applications. As with any health care intervention, such claims require confirmation in …

rin. 25, 26 Inhibition of S-warfarin metabolism is more important clinically because this
isomer is 5 times more potent than the R-isomer as a vitamin K antagonist. 25, 26 …

Background The opportunity to improve care by delivering decision support to clinicians at
the point of care represents one of the main incentives for implementing sophisticated …

Oral anticoagulants are a mainstay of cardiovascular therapy, and for over 60 years vitamin
K antagonists (VKAs) were the only available agents for long-term use. VKAs interfere with …

Current dosing algorithms do not account for genetic and environmental factors for warfarin
dose determinations. This study investigated the contribution of age, CYP2C9 and VKORC1 …

Adverse drug reactions (ADRs) are a major clinical problem. Genetic factors can determine
individual susceptibility to both dose-dependent and dose-independent ADRs. Determinants …

Objective The objective of this study was to assess the contribution of the VKORC1 and
CYP2C9 genotypes and age, body size, and weight of the patients to the warfarin dose …

Warfarin is the most widely prescribed oral anticoagulant, but there is greater than 10-fold
interindividual variability in the dose required to attain a therapeutic response. Information …