[HTML][HTML] The fibrosis-cell death axis in heart failure
Cardiac stress can induce morphological, structural and functional changes of the heart,
referred to as cardiac remodeling. Myocardial infarction or sustained overload as a result of …
referred to as cardiac remodeling. Myocardial infarction or sustained overload as a result of …
Left ventricular remodeling after myocardial infarction: pathophysiology and therapy
MGSJ Sutton, N Sharpe - Circulation, 2000 - Am Heart Assoc
renin-angiotensin-aldosterone system, and stimulates the production of atrial and brain
natriuretic peptides (ANP and BNP). 10 Augmented shortening and increased heart rate …
natriuretic peptides (ANP and BNP). 10 Augmented shortening and increased heart rate …
[HTML][HTML] FGF23 induces left ventricular hypertrophy
Chronic kidney disease (CKD) is a public health epidemic that increases risk of death due to
cardiovascular disease. Left ventricular hypertrophy (LVH) is an important mechanism of …
cardiovascular disease. Left ventricular hypertrophy (LVH) is an important mechanism of …
Regulation of blood pressure and salt homeostasis by endothelin
DE Kohan, NF Rossi, EW Inscho… - Physiological …, 2011 - journals.physiology.org
Endothelin (ET) peptides and their receptors are intimately involved in the physiological
control of systemic blood pressure and body Na homeostasis, exerting these effects through …
control of systemic blood pressure and body Na homeostasis, exerting these effects through …
[HTML][HTML] Neuregulins promote survival and growth of cardiac myocytes: persistence of ErbB2 and ErbB4 expression in neonatal and adult ventricular myocytes
Y Zhao, DR Sawyer, RR Baliga, DJ Opel, X Han… - Journal of Biological …, 1998 - ASBMB
Neuregulins (ie neuregulin-1 (NRG1), also called neu differentiation factor, heregulin, glial
growth factor, and acetylcholine receptor-inducing activity) are known to induce growth and …
growth factor, and acetylcholine receptor-inducing activity) are known to induce growth and …
Mechanical stress-induced cardiac hypertrophy: mechanisms and signal transduction pathways
C Ruwhof, A van der Laarse - Cardiovascular research, 2000 - academic.oup.com
Cardiac hypertrophy is a well known response to increased hemodynamic load. Mechanical
stress is considered to be the trigger inducing a growth response in the overloaded …
stress is considered to be the trigger inducing a growth response in the overloaded …
Cytoplasmic signaling pathways that regulate cardiac hypertrophy
JD Molkentin, GW Dorn II - Annual review of physiology, 2001 - annualreviews.org
▪ Abstract This review discusses the rapidly progressing field of cardiomyocyte signal
transduction and the regulation of the hypertrophic response. When stimulated by a wide …
transduction and the regulation of the hypertrophic response. When stimulated by a wide …
Elements of a single MAP kinase cascade in Saccharomyces cerevisiae mediate two developmental programs in the same cell type: mating and invasive growth.
RL Roberts, GR Fink - Genes & development, 1994 - genesdev.cshlp.org
Diploid Saccharomyces cerevisiae strains starved for nitrogen undergo a developmental
transition from a colonial form of growth to a filamentous pseudohyphal form. This …
transition from a colonial form of growth to a filamentous pseudohyphal form. This …
[HTML][HTML] The conserved phosphoinositide 3-kinase pathway determines heart size in mice
T Shioi, PM Kang, PS Douglas, J Hampe… - The EMBO …, 2000 - embopress.org
Phosphoinositide 3-kinase (PI3K) has been shown to regulate cell and organ size in
Drosophila, but the role of PI3K in vertebrates in vivo is not well understood. To examine the …
Drosophila, but the role of PI3K in vertebrates in vivo is not well understood. To examine the …
Angiotensin II stimulates cardiac myocyte hypertrophy via paracrine release of TGF-β1 and endothelin-1 from fibroblasts
MO Gray, CS Long, JE Kalinyak, HT Li… - Cardiovascular …, 1998 - academic.oup.com
Objective: We sought to determine whether angiotensin II (Ang II) promotes hypertrophy of
cardiac myocytes directly or via paracrine mechanisms mediated by cardiac fibroblasts …
cardiac myocytes directly or via paracrine mechanisms mediated by cardiac fibroblasts …