Thyroglobulin (Tg) is a vertebrate secretory protein synthesized in the thyrocyte endoplasmic
reticulum (ER), where it acquires N-linked glycosylation and conformational maturation …

The purpose of this review is to summarize current knowledge of the etiology of euthyroid
and toxic multinodular goiter (MNG) with respect to the epidemiology, clinical characteristics …

Thyroglobulin (TG) defects due to TG gene mutations have an estimated incidence of
approximately 1 in 100,000 newborns. This dyshormonogenesis displays a wide phenotype …

Thyroglobulin (TG) plays a main role in the biosynthesis of thyroid hormones (TH), and, thus,
it is involved in a wide range of vital functions throughout the life cycle of all vertebrates …

Human thyroglobulin (TG) gene is a single copy gene, 270 kb long, that maps on
chromosome 8q24. 2–8q24. 3 and contains an 8.5-kb coding sequence divided into 48 …

Iodine deficiency is the most important etiological factor for euthyroid endemic goiter.
However, family and twin pair studies also indicate a genetic predisposition for euthyroid …

In a 22-yr-old healthy woman, a fetal goiter was diagnosed coincidentally by ultrasound
during the sixth month of gestation, and hypothyroidism was affirmed by a high TSH (336 …

Synthesis of tri-iodothyronine (T3) and thyroxine (T4) follows a metabolic pathway that
depends on the integrity of the thyroglobulin structure. This large glycoprotein is a …

In this study, we have extended our initial molecular studies of a nonconsanguineous family
with two affected siblings and one of their nephews with congenital goiter, hypothyroidism …

Thyroid dyshormonogenesis due to thyroglobulin (TG) gene mutations have an estimated
incidence of approximately 1 in 100,000 newborns. The clinical spectrum ranges from …