Autonomic nervous system dysfunction throughout menopausal transition: A potential mechanism underpinning cardiovascular and cognitive alterations during female …

KG Schwarz, SC Vicencio, NC Inestrosa… - The Journal of …, 2024 - Wiley Online Library
Cardiovascular diseases (CVD) and neurodegenerative disorders, such as Alzheimer's
disease (AD), are highly prevalent conditions in middle‐aged women that severely impair …

Adrenergic supersensitivity and impaired neural control of cardiac electrophysiology following regional cardiac sympathetic nerve loss

S Tapa, L Wang, SD Francis Stuart, Z Wang, Y Jiang… - Scientific reports, 2020 - nature.com
Myocardial infarction (MI) can result in sympathetic nerve loss in the infarct region. However,
the contribution of hypo-innervation to electrophysiological remodeling, independent from MI …

Cardiorespiratory alterations following intermittent photostimulation of RVLM C1 neurons: implications for long‐term blood pressure, breathing and sleep regulation in …

C Toledo, DC Andrade, E Diaz‐Jara… - Acta …, 2022 - Wiley Online Library
Aim Sympathoexcitation and sleep‐disordered breathing are common contributors for
disease progression. Catecholaminergic neurons from the rostral ventrolateral medulla …

Potential role of the retrotrapezoid nucleus in mediating cardio-respiratory dysfunction in heart failure with preserved ejection fraction

C Toledo, D Ortolani, FC Ortiz, NJ Marcus… - Frontiers in …, 2022 - frontiersin.org
A strong association between chemoreflex hypersensitivity, disordered breathing, and
elevated sympathetic activity has been shown in experimental and human heart failure (HF) …

Exercise training reduces brainstem oxidative stress and restores normal breathing function in heart failure

E Díaz-Jara, HS Díaz, A Rios-Gallardo… - Free Radical Biology …, 2021 - Elsevier
Enhanced central chemoreflex drive and irregular breathing are both hallmarks in heart
failure (HF) and closely related to disease progression. Central chemoreceptor neurons …

Inhibition of brainstem endoplasmic reticulum stress rescues cardiorespiratory dysfunction in high output heart failure

HS Díaz, DC Andrade, C Toledo, KG Schwarz… - …, 2021 - Am Heart Assoc
Recent evidence shows that chronic activation of catecholaminergic neurons of the rostral
ventrolateral medulla is crucial in promoting autonomic imbalance and cardiorespiratory …

Whole‐Heart 4D Flow MRI for Evaluation of Normal and Regurgitant Valvular Flow: A Quantitative Comparison Between Pseudo‐Spiral Sampling and EPI Readout

CPS Blanken, LM Gottwald… - Journal of Magnetic …, 2022 - Wiley Online Library
Background Pseudo‐spiral Cartesian sampling with compressed sensing reconstruction has
facilitated highly accelerated 4D flow magnetic resonance imaging (MRI) in various …

Medullary astrocytes mediate irregular breathing patterns generation in chronic heart failure through purinergic P2X7 receptor signalling

C Toledo, E Díaz-Jara, HS Diaz, KG Schwarz… - …, 2022 - thelancet.com
Background Breathing disorders (BD)(apnoeas/hypopneas, periodic breathing) are highly
prevalent in chronic heart failure (CHF) and are associated with altered central respiratory …

Paraquat herbicide diminishes chemoreflex sensitivity, induces cardiac autonomic imbalance and impair cardiac function in rats

KV Pereyra, KG Schwarz… - American Journal …, 2021 - journals.physiology.org
Paraquat (PQT) herbicide is widely used in agricultural practices despite being highly toxic
to humans. It has been proposed that PQT exposure may promote cardiorespiratory …

Effects of enriched-potassium diet on cardiorespiratory outcomes in experimental non-ischemic chronic heart failure

KG Schwarz, KV Pereyra, C Toledo, DC Andrade… - Biological …, 2021 - SciELO Chile
SCHWARZ, Karla G. et al. Effects of enriched-potassium diet on cardiorespiratory outcomes
in experimental non-ischemic chronic heart failure. Biol. Res.[online]. 2021, vol. 54, 43. Epub …