Role of LOX-1 (lectin-like oxidized low-density lipoprotein receptor 1) as a cardiovascular risk predictor: mechanistic insight and potential clinical use

J Barreto, SK Karathanasis, A Remaley… - … , and vascular biology, 2021 - Am Heart Assoc
Atherosclerosis, the underlying cause of cardiovascular disease (CVD), is a worldwide
cause of morbidity and mortality. Reducing ApoB-containing lipoproteins—chiefly, LDL (low …

Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1): a crucial driver of atherosclerotic cardiovascular disease

A Akhmedov, T Sawamura, CH Chen… - European heart …, 2021 - academic.oup.com
Cardiovascular diseases (CVDs), specifically lipid-driven atherosclerotic CVDs, remain the
number one cause of death worldwide. The lectin-like oxidized low-density lipoprotein (LDL) …

Inflammation, autoimmunity, infection, and stroke: epidemiology and lessons from therapeutic intervention

NS Parikh, AE Merkler, C Iadecola - Stroke, 2020 - Am Heart Assoc
712 Stroke March 2020 outcome of stroke. 27, 28 Rosuvastatin reduced stroke risk in
subjects who either achieved LDL-C levels of< 70 mg/dL or hs-CRP levels of< 2 mg/L …

Soluble lectin-like oxidized low-density lipoprotein receptor-1 predicts premature death in acute coronary syndromes

S Kraler, FA Wenzl, G Georgiopoulos… - European heart …, 2022 - academic.oup.com
Aims The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) and its shedding
product [soluble LOX-1 (sLOX-1)] are implicated in atherosclerotic cardiovascular disease …

[HTML][HTML] The mannose receptor: from endocytic receptor and biomarker to regulator of (meta) inflammation

HJP van der Zande, D Nitsche, L Schlautmann… - Frontiers in …, 2021 - frontiersin.org
The mannose receptor is a member of the C-type lectin (CLEC) family, which can bind and
internalize a variety of endogenous and pathogen-associated ligands. Because of these …

Sex-specific association of visceral and subcutaneous adipose tissue volumes with systemic inflammation and innate immune cells in people living with obesity

ICL van den Munckhof, H Bahrar, K Schraa… - International Journal of …, 2024 - nature.com
Background and aims Obesity predisposes to metabolic and cardiovascular diseases.
Adipose tissue inflammation and systemic inflammation contribute to these complications …

Search for reliable circulating biomarkers to predict carotid plaque vulnerability

N Puig, E Jiménez-Xarrié, P Camps-Renom… - International journal of …, 2020 - mdpi.com
Atherosclerosis is responsible for 20% of ischemic strokes, and the plaques from the internal
carotid artery the most frequently involved. Lipoproteins play a key role in carotid …

Non-stenotic carotid plaques in embolic stroke of unknown source

J Kamtchum-Tatuene, AZ Nomani, S Falcione… - Frontiers in …, 2021 - frontiersin.org
Embolic stroke of unknown source (ESUS) represents one in five ischemic strokes.
Ipsilateral non-stenotic carotid plaques are identified in 40% of all ESUS. In this narrative …

The critical role of endothelial function in fine particulate matter-induced atherosclerosis

S Liang, J Zhang, R Ning, Z Du, J Liu… - Particle and Fibre …, 2020 - Springer
Ambient and indoor air pollution contributes annually to approximately seven million
premature deaths. Air pollution is a complex mixture of gaseous and particulate materials. In …

Soluble LOX‐1: a novel biomarker in patients with coronary artery disease, stroke, and acute aortic dissection?

A Hofmann, C Brunssen, S Wolk, C Reeps… - Journal of the …, 2020 - Am Heart Assoc
Cardiovascular diseases are the leading cause of death worldwide. Approximately 85% of
all deaths from cardiovascular disease are due to acute myocardial infarction (AMI) and …