Alternative splicing (AS) generates remarkable regulatory and proteomic complexity in
metazoans. However, the functions of most AS events are not known, and programs of …

Alternative splicing (AS) is a critical regulatory layer; yet, factors controlling functionally
coordinated splicing programs during developmental transitions are poorly understood …

Our understanding of the molecular determinants of cancer is still inadequate because of
cancer heterogeneity. Here, using epithelial ovarian cancer (EOC) as a model system, we …

Insulin expression is primarily restricted to the pancreatic β cells, which are physically or
functionally depleted in diabetes. Identifying targetable pathways repressing insulin in non-β …

Progressive failure of insulin-producing β-cells is the central event leading to diabetes, but
the signaling networks controlling β-cell fate remain poorly understood. Here we show that …

Alterations in RNA-splicing are a molecular hallmark of several neurological diseases,
including muscular dystrophies where mutations in genes involved in RNA metabolism or …

Post-transcriptional gene regulation is a fundamental mechanism that helps regulate the
development and healthy aging of the nervous system. Mutations that disrupt the function of …

RNA binding proteins (RBPs) play a fundamental role in the post-transcriptional regulation
of gene expression within the germline and nervous system. This is underscored by the …

Alternative splicing is a key mechanism that shapes neuronal transcriptomes, helping to
define neuronal identity and modulate function. Here, we present an atlas of alternative …

Aging-related diseases result in numerous forms of decline including reduction in fertility
and decrease in lifespan. Furthermore, many aging diseases have ties to …