High serum lactate dehydrogenase (LDH) levels are typically associated with a poor
prognosis in many cancer types. Even the most effective drugs, which have radically …

N ε-lysine acetylation was discovered more than half a century ago as a post-translational
modification of histones and has been extensively studied in the context of transcription …

Piezoelectric nanomaterials that can generate reactive oxygen species (ROS) by
piezoelectric polarization under an external mechanical force have emerged as an effective …

Elevated glycolysis remains a universal and primary character of cancer metabolism, which
deeply depends on dysregulated metabolic enzymes. Lactate dehydrogenase A (LDHA) …

Pancreatic cancer is currently one of the most lethal diseases. In recent years, increasing
evidence has shown that reprogrammed metabolism may play a critical role in the …

Protein post-translational modifications (PTMs) profoundly influence protein functions and
play crucial roles in essentially all cell biological processes. The diverse realm of PTMs and …

Pancreatic ductal adenocarcinoma is prone to distant metastasis and is expected to become
the second leading cause of cancer-related death. In an extremely nutrient-deficient and …

There are over 120 types of brain tumor and approximately 45% of primary brain tumors are
gliomas, of which glioblastoma multiforme (GBM) is the most common and aggressive with a …

The growing field of tumor metabolism has greatly expanded our knowledge of metabolic
reprogramming in cancer. Apart from their established roles, various metabolic enzymes and …

Lactate dehydrogenase (LDH) is a terminating enzyme in the metabolic pathway of
anaerobic glycolysis with end product of lactate from glucose. The lactate formation is crucial …