5-Aminovaleric acid betaine (5-AVAB) is a trimethylated compound associated with the gut
microbiota, potentially produced endogenously, and related to the dietary intake of certain …

Background Preeclampsia (PE) is a significant cause of maternal and neonatal morbidity
and mortality worldwide. However, the pathogenesis of PE is unclear and reliable early …

Background The maternal microbiota affects the development of the offspring by microbial
metabolites translocating to the fetus. To reveal the spectrum of these molecular mediators …

Dried blood spot (DBS) metabolite analysis is a central tool for the clinic, eg, newborn
screening. Instead of applying multiple analytical methods, a single liquid chromatography …

Introduction: Tryptophan is the precursor of kynurenine pathway (KP) metabolites which
regulate immune tolerance, energy metabolism, and vascular tone. Since these processes …

Pregnancy is a finely tuned process, with the health and well‐being of the developing fetus
determined by the metabolic status and dietary intake of the mother. The maternal gut …

BACKGROUND: The serum metabolome is a potential source of molecular biomarkers
associated with the risk of breast cancer. Here we aimed to analyze metabolites present in …

Gestational hyperandrogenism is a risk factor for adverse maternal and offspring outcomes
with effects likely mediated in part via disruptions in maternal lipid homeostasis. Using a …

Pregnancy induces dramatic metabolic changes in females; yet, the intricacies of this
metabolic reprogramming remain poorly understood, especially in primates. Using …

Abstract Background 5-Aminovaleric acid betaine (5-AVAB) has recently been identified as
a diet and microbial-dependent factor inducing obesity and hepatic steatosis in mice fed a …