Design, Synthesis, and Antiviral Evaluation of Sialic Acid Derivatives as Inhibitors of Newcastle Disease Virus Hemagglutinin-Neuraminidase: A Translational Study …

P Rota, P La Rocca, F Bonfante, M Pagliari… - ACS Infectious …, 2023 - ACS Publications
Global infections with viruses belonging to the Paramyxoviridae, such as Newcastle disease
virus (NDV) or human parainfluenza viruses (hPIVs), pose a serious threat to animal and …

[PDF][PDF] A review on biological activities of sugars and sugar derivatives

SE Spriha, SMA Rahman - Dhaka University Journal of …, 2022 - researchgate.net
Sugar and sugar derivatives have numerous reported biological activities. Sugar moieties in
many therapeutically important compounds have influence on their pharmacological …

Intramolecular lactones of sialic acids

P Rota, P La Rocca, P Allevi, C Pappone… - International Journal of …, 2020 - mdpi.com
The so-called “sialo-chemical-biology” has become an attractive research area, as an
increasing number of natural products containing a sialic acid moiety have been shown to …

Using pre‐gelatinised red lentils in pasta production: connecting starch features and pasta cooking behaviour

A Bresciani, G Giuberti, M Cervini… - International Journal of …, 2023 - Wiley Online Library
Considering the high interest in using pulses in the production of staple foods, including
pasta, this study aimed at investigating the effect of pre‐gelatinisation on the overall quality …

Interplay of Modified Sialic Acid Inhibitors and the Human Parainfluenza Virus 1 Hemagglutinin-Neuraminidase Active Site

P Rota, P La Rocca, F Bonfante… - ACS Medicinal …, 2023 - ACS Publications
In the search for effective antivirals against Paramyxoviridae, the dynamics of human
parainfluenza virus type 1 hemagglutinin-neuraminidase (hPIV1-HN) inhibition offers a …

Small-Molecules as Chemiluminescent Probes to Detect Lipase Activity

P La Rocca, A Mingione, S Casati, R Ottria… - International Journal of …, 2022 - mdpi.com
The set-up of highly sensitive detection tools to evaluate lipase activity remains a central
goal in different fields. In this context, we proposed new chemiluminescent 1, 2-dioxetane …

Potent Inhibitors against Newcastle Disease Virus Hemagglutinin‐Neuraminidase

P Rota, P La Rocca, M Piccoli, M Montefiori… - …, 2018 - Wiley Online Library
Neuraminidase activity is essential for the infection and propagation of paramyxoviruses,
including human parainfluenza viruses (hPIVs) and the Newcastle disease virus (NDV) …

Lactonization Method To Assign the Anomeric Configuration of the 3,4-Unsaturated Congeners of N-Acetylneuraminic Acid

P La Rocca, P Rota, M Piccoli, F Cirillo… - The Journal of …, 2019 - ACS Publications
Assigning the correct configuration at C2 in sialosides is a standing problem because of the
absence of an anomeric hydrogen. All different empirical rules that have been proposed …

The acidic hydrolysis of N-acetylneuraminic 4, 5-oxazoline allows a direct functionalization of the C5 position of Neu5Ac2en (DANA)

P Rota, P La Rocca, F Cirillo, M Piccoli, P Allevi… - RSC …, 2020 - pubs.rsc.org
The acidic hydrolysis of N-acetylneuraminic 4, 5-oxazoline affords the corresponding 2, 3-
unsaturated amino ester, which was not previously detected (nor isolated) due to the …

2β-3, 4-Unsaturated sialic acid derivatives: Synthesis optimization, and biological evaluation as Newcastle disease virus hemagglutinin-neuraminidase inhibitors

P La Rocca, P Rota, M Piccoli, F Cirillo… - Bioorganic & Medicinal …, 2020 - Elsevier
The optimization of the synthetic protocol to obtain the 3, 4-unsaturated sialic acid
derivatives, through the fine-tuning of both the Ferrier glycosylation conditions and the …