The road to fully programmable protein catalysis
The ability to design efficient enzymes from scratch would have a profound effect on
chemistry, biotechnology and medicine. Rapid progress in protein engineering over the past …
chemistry, biotechnology and medicine. Rapid progress in protein engineering over the past …
Enantioselective radical reactions using chiral catalysts
Benefiting from the impressive increase in fundamental knowledge, the last 20 years have
shown a continuous burst of new ideas and consequently a plethora of new catalytic …
shown a continuous burst of new ideas and consequently a plethora of new catalytic …
Strain-release photocatalysis
P Bellotti, F Glorius - Journal of the American Chemical Society, 2023 - ACS Publications
The concept of strain in organic compounds is as old as modern organic chemistry and was
initially introduced to justify the synthetic setbacks along the synthesis of small ring systems …
initially introduced to justify the synthetic setbacks along the synthesis of small ring systems …
Photoredox-catalyzed C–H functionalization reactions
N Holmberg-Douglas, DA Nicewicz - Chemical reviews, 2021 - ACS Publications
The fields of C–H functionalization and photoredox catalysis have garnered enormous
interest and utility in the past several decades. Many different scientific disciplines have …
interest and utility in the past several decades. Many different scientific disciplines have …
Radical philicity and its role in selective organic transformations
Radical intermediates in organic chemistry lack a full octet of electrons and, thus, are
commonly said to be electron deficient. By denotation, such a statement is technically …
commonly said to be electron deficient. By denotation, such a statement is technically …
Visible‐light photocatalysis: does it make a difference in organic synthesis?
Visible‐light photocatalysis has evolved over the last decade into a widely used method in
organic synthesis. Photocatalytic variants have been reported for many important …
organic synthesis. Photocatalytic variants have been reported for many important …
Electrochemical carbon–carbon coupling with enhanced activity and racemate stereoselectivity by microenvironment regulation
K Kong, AZ Li, Y Wang, Q Shi, J Li, K Ji… - Nature …, 2023 - nature.com
Enzymes are characteristic of catalytic efficiency and specificity by maneuvering multiple
components in concert at a confined nanoscale space. However, achieving such a …
components in concert at a confined nanoscale space. However, achieving such a …
Copper-catalyzed radical relay for asymmetric radical transformations
F Wang, P Chen, G Liu - Accounts of Chemical Research, 2018 - ACS Publications
Conspectus The direct transformation of C–H bonds into diverse functional groups
represents one of the most atom-and step-economical strategies for organic synthesis and …
represents one of the most atom-and step-economical strategies for organic synthesis and …
Photoredox catalysis in organic chemistry
In recent years, photoredox catalysis has come to the forefront in organic chemistry as a
powerful strategy for the activation of small molecules. In a general sense, these approaches …
powerful strategy for the activation of small molecules. In a general sense, these approaches …
Using physical organic chemistry to shape the course of electrochemical reactions
KD Moeller - Chemical reviews, 2018 - ACS Publications
While organic electrochemistry can look quite different to a chemist not familiar with the
technique, the reactions are at their core organic reactions. As such, they are developed and …
technique, the reactions are at their core organic reactions. As such, they are developed and …