The melanocortin 1 receptor (MC1R) is a melanocytic Gs protein coupled receptor that
regulates skin pigmentation, UV responses, and melanoma risk. It is a highly polymorphic …

G protein-coupled receptors (GPCRs) are historically the most successful family of drug
targets. In recent times it has become clear that the pharmacology of these receptors is far …

A bíblia azul da farmacologia–assim tem sido mundialmente chamado este clássico
acadêmico desde o lançamento de sua 1ª edição, em 1941. A nova edição de Goodman & …

Constitutive receptor activity/inverse agonism and functional selectivity/biased agonism are
2 concepts in contemporary pharmacology that have major implications for the use of drugs …

The study of the magnitude and variation of drug response is defined as pharmacodynamics
(PDs). PD models examine plasma concentration and effect relationship. It can predict the …

Mammalian oocytes grow and undergo meiosis within ovarian follicles. Oocytes are arrested
at the first meiotic prophase, held in meiotic arrest by the surrounding follicle cells until a …

Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

Hepatic fibrosis, the common response associated with chronic liver diseases, ultimately
leads to cirrhosis, a major public health problem worldwide. We recently showed that …

The important family of G protein-coupled receptors has so far not been targeted very
successfully with conventional monoclonal antibodies. Here we report the isolation and …

Activation of Kupffer cells plays a central role in the pathogenesis of alcoholic liver disease.
Because cannabinoid CB2 receptors (CB2) display potent anti‐inflammatory properties, we …